David's theory of evolution: God's error corrections II (Evolution)

by David Turell @, Friday, November 06, 2020, 20:55 (349 days ago) @ David Turell

Another repair and control mechanism in mouse embryology:


"In a study published in Science Advances, a team led by Prof. Zheng Ping from Kunming Institute of Zoology of the Chinese Academy of Sciences (CAS),... provided the first proof of concept demonstrating the region-specific regulations of double strand break (DSB) formation and repair in subtypes of neural stem/progenitor cells (NSPCs). In this study, the researchers identified a regional regulator, Filia, which is predominantly expressed in mouse hippocampal NSPCs after birth, and regulates DNA DSB formation.

"Studying how stem cells maintain genomic stability can help advance the safe use of stem cells and understand the pathogenesis of related developmental diseases. Prof. Zheng's lab has identified that Filia regulates the genomic stability of embryonic stem cells, revealing its pathways, and found that mutations of human homologous genes cause embryonic development failure and recurrent abortion.

"Compared with embryonic stem cells, tissue stem cells have only specific developmental potential. To investigate whether they have some common regulatory mechanisms for maintaining genomic stability, the researchers investigated the expression and function of Filia in NSPCs of mice. Intriguingly, they found that Filia was expressed in cultured hippocampal NSPCs and responded to exogenous DNA damage.


"This study revealed that Filia specifically regulates genomic stability and neurogenesis of hippocampal NSPCs, and provided the first proof of concept demonstrating the region specific regulations of DSBs formation and repair in hippocampal NSPCs.

"Stem cells are the basis of organism development and tissue homeostasis, and genomic stability is prerequisite for stem cell maintenance and regenerative medicine application."

Comment: As usual, another discovery of God's protective editing mechanisms in embryology. More clear evidence of God's recognition of problems in free-moving and responding molecules that are required for our God-given system of living biochemistry.

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