David's theory of evolution Part Two: humans are final (Evolution)

by David Turell @, Monday, January 13, 2020, 19:04 (4 days ago) @ David Turell

Humans are changing genetics and are in control of evolution:


"A research team led by Profs. Gao Caixia and LI Jiayang from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences have engineered five saturated targeted endogenous mutagenesis editors (STEMEs) and generated de novo mutations to facilitate the directed evolution of plant genes.


"'To establish powerful tools for directly inducing saturated targeted mutations and selection in plants will accelerate the development of agronomic traits and important functional genes," said Prof. Gao Caixia.

"The researchers fused cytidine deaminase with adenosine deaminase to obtain four STEMEs. All four STEMEs efficiently produced simultaneous C>T and A>G conversions using only a sgRNA.
They also produced the fifth dual cytosine and adenine base editor—STEME-NG—to expand the targeting scope. With only 20 sgRNAs in rice protoplasts, STEME-NG can produce near-saturated mutagenesis for a 56-amino-acid portion of the rice acetyl-coenzyme A carboxylase gene (OsACC).

"In a proof-of-concept experiment, the researchers used STEMEs to direct the evolution of OsACC gene in rice plants. They sprayed the regenerated rice seedlings with haloxyfop as the selection pressure. The scientists then identified three novel (P1927F, W2125C, and S1866F) and one known (W2125C) amino acid substitutions for herbicide resistance. These mutations were found to affect the haloxyfop-binding pocket directly or indirectly, based on the homology model of the CT domain of yeast ACC.

"The development of STEME paves the way for directed evolution of endogenous plant genes in situ, which is important for breeding via molecular design.

"Moreover, this STEME process might also be applicable beyond plants. For example, it may be useful for screening drug resistance mutations, altering cis elements on noncoding regions and correcting pathogenic SNVs in cell lines, yeast or animals. "

Comment: Note how we are designing evolution. Not hard to imagine God doing this. In China one scientist has been arrested after trying to produce designer babies!

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