Natures wonders: bacterial gut help (Introduction)

by David Turell , Friday, June 23, 2023, 18:47 (309 days ago) @ David Turell

What humans eat determines the gut microbiome and how it acts:

https://www.nature.com/articles/d41586-023-02065-y?utm_source=Nature+Briefing&utm_c...

"The human gut is teeming with trillions of microbes, but most studies of this vast community have focused on people living in urban regions. Now, a team of researchers has sequenced gut microbiomes from Hadza people — members of a hunter-gatherer society in northern Tanzania — and compared them with those from people in Nepal and California1. The study has found not only that the Hadza tend to have more gut microorganisms than people in the other groups, but that a Western lifestyle seems to diminish the diversity of gut populations.

"The Hadza had an average of 730 species of gut microbe per person. The average Californian gut microbiome contained just 277 species, and the Nepali microbiomes fell in between. People with a farming-based lifestyle had an average of 436 microbe species, whereas those who live by foraging had an average of 317.

"The team also found species in the Hadza microbiomes that were not present in the Californian samples, such as the corkscrew-shaped bacterium Treponema succinifaciens. Only some of the Nepali microbiomes contained this microbe, suggesting that the bacterium is dying out as societies become more industrialized.

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"The researchers sequenced microbiomes from fecal samples collected from 167 Hadza people — including infants and mothers — between 2013 and 2014. For comparison, the team also generated sequences from stool samples collected from four groups of people in Nepal in 2016, and samples from Californian participants in a 2021 study2 that explored how diet affects the microbiome.

"From these samples, Sonnenburg and his team sequenced more than 90,000 genomes from microbes found in the human gut, including bacteria, viruses that infect bacteria, and single-celled organisms from groups called archaea and eukaryotes. Some 44% of these microbial genomes had not yet been recorded in large catalogues such as the Unified Human Gastrointestinal Genome database. Among the genome sequences recovered from the Hadza samples, more than 1,000 were from bacterial or archaeal species that are new to science.

"Furthermore, gut-microbe species commonly found in industrialized populations often contained genes associated with responding to oxidative damage. The team suspects chronic inflammation in the gut could trigger such damage, creating a selective pressure for those genes, says study co-author Matthew Olm, a microbiologist at Stanford. “If you have a state of chronic inflammation, it would make sense that your gut microbiome has to adapt,” he says. These genes were not detected in the Hadza microbiomes."

Comment: most bacteria are very helpful and necessary. They are not the evil dhw portrays. It is when bacteria get in the wrong places that trouble develops. And God cannot control free-living organisms.