Big brain evolution: memory at molecular level (Evolution)

by David Turell @, Monday, April 23, 2018, 19:23 (237 days ago) @ dhw

Studies at the synapses show somewhat how memory works. Memory is retained thought from the s/s/c:

"When we learn the connections between neurons strengthen. Addiction or other neurological diseases are linked to abnormally strong connections. But what does learning look like on the cellular and molecular level? How do our cells change when we learn? Using super-resolution live-cell microscopy, researchers at Thomas Jefferson University zoomed into the connections between neurons that strengthen to discover structural changes that had never been seen before.


"Rather than simply seeing bigger connections during learning, which has been observed before, Dr. Dalva and his colleagues found that the molecules involved in sending and receiving the signals between neurons appeared to be organized in clumps or "nanomodules" that both dance and multiply when stimulated by learning-like signals.

"The researchers made their observations using living neurons in real-time, zooming into synapses, the sites of neuronal connection where information is passed from one cell to another to enable learning and other behavior. Dr. Dalva's colleagues visualized the key molecules involved in the neurotransmission from neuron to neuron with two colors, green on sending side (the pre-synaptic side) and red on the receiving side (postsynaptic side).

"The team made a number of surprising observations about the synaptic nanomodules. They saw that the key molecules on the presynaptic side clumped together and tracked, as if linked, to the key molecules clumped on the postsynaptic side. These pre/post molecular clumps or nanomodules appear to have a uniform size. They also multiplied when the neurons were stimulated in a way that mimicked changes in the size of the spines which protrude from neurons to nearly touch at the synapse. And as the number of nanomodules increased, so did the size of the spines. "The key finding is that changes in synaptic strength might be more digital than analog - with same sized units added to change synaptic strength," said Dr. Dalva.

"Another surprise was how the nanomodules behaved when stimulated. "When we activated the neuron with signals that would strengthen the synaptic connection, a non-moving nanomodule would begin to jiggle and move around the synaptic spine, with the pre- and post-synaptic components always in lock step," said first author Dr. Martin Hruska, an Instructor in Dr. Dalva's lab."

Comment: The work of the s/s/c is represented by work at the molecular level. No way to separate the material and the immaterial.

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