Biological complexity: a cell repair design (Introduction)

by David Turell , Saturday, December 18, 2021, 14:46 (1071 days ago) @ David Turell

Repair of the nucleus membrane specificity:

https://www.science.org/doi/10.1126/science.acz9827?utm_campaign=ec_sci_2021-12-16

"The cell nucleus is surrounded by a double membrane structure known as the nuclear envelope (NE). Ruptures in the NE compromise nuclear-cytoplasmic compartmentalization and contribute to genome instability and pro-inflammatory responses. Resealing of the wounded NE is mediated by the Endosomal Sorting Complex Required for Transport (ESCRT) machinery, a highly conserved membrane-remodeling pathway. During repair, the mechanical strain imposed by the cytoskeleton needs to be relieved to counteract intranuclear pressure. Wallis et al. found that the ESCRT-associated protein BROX regulates the mechanical properties of the NE during repair. BROX bound to the nucleoskeleton-cytoskeleton linker protein Nesprin-2G and promoted its removal from compression sites, which facilitated efficient membrane resealing and protected genetic material from damage."

Comment: This system shows the designer recognized damage could happen and provided a repair system. Design requires understanding the future problems that mistakes will cause. We know this biochemistry of life creates life. We do not know if another system can work. Stating that possibility second-guesses the designer, who probably stuck with this working design as the only one available..