Biological complexity: repair of nerves (Introduction)

by David Turell , Saturday, August 25, 2018, 19:08 (2282 days ago) @ David Turell

When neurons appeared in evolution and created nerve networks, a repair mechanism had to appear at the same time. The mechanism:

https://medicalxpress.com/news/2018-08-cascade-nerve-cells-characterized.html

"Through a study of roundworm nerve cells with severed axons, researchers at Nagoya University showed that a signaling cascade that normally functions in promoting the phagocytosis of apoptotic cells also acts in inducing axon regeneration. The findings shed light on a fundamental feature of nerve repair, which is limited in the central nervous system in humans, and thus could pave the way towards treatments for brain and spinal cord injuries.

"Researchers have identified the series of molecules involved in the regeneration of damaged nerves in roundworm, showing that it largely overlaps with the signals used by the intrinsic removal system to take up and process dying cells.

"The branches of nerve cells called axons are particularly susceptible to damage due to the long distances they extend to communicate with each other. In humans,such damage in peripheral regions of the body can be relatively well repaired,but this repair is less effective in the brain and the spinal cord, which helps to explain why conditions such as brain and spinal cord injuries are so debilitating.

***

"The team used a laser to cut roundworm axons and then analyzed the subsequent series of molecular reactions that occurred. They found that this damage resulted in the movement of a lipid called phosphatidylserine (PS) from the inside of cells to their outside,which was mediated by a protein called an ABC transporter. This externalized PS was then recognized by another molecule, triggering a series of reactions that eventually led to repair of the axon. Interestingly, PS is better known as an "eat me" signal that helps the phagocytosis of a dying cell by its neighbors.

"'We were able to dissect the complex range of molecules involved in axon repair by using fluorescent labels in and around the severed axon and knocking down the individual components suspected of being involved,"says corresponding author Kunihiro Matsumoto."Although many of these molecules are also active in promoting phagocytosis of apoptotic cells,in axon repair that creates a "save me" signal rather than an "eat me" one,which enables the axons to regenerate."

"The team explains that for the repair of damaged nerves,the PS labeling appears only at the severed sites and exists for only a short time(~1 hr),which is in contrast to the labeling in eliminating dying cells that remains for a long time until the cells are eliminated. The researchers now guess that this difference in signal timing may be one way for the cells to distinguish the meaning of the PS signal -"eat me" vs. "save me.'"

Comment: It seems reasonable to assume that this repair system was designed when nerve networks also appeared becasue such protection s were needed from the beginning.