Biological complexity: respiratory mitochondrial form (Introduction)

by David Turell , Tuesday, September 06, 2016, 19:20 (3000 days ago) @ David Turell

This is another of the huge complex molecules necessary for multicellular life. In a blind search of possible functional molecular structure, as proposed by 'Darwin chance', just how was this found? This is one example of thousands of huge complex molecules necessary for life if one adds up all the different enzymes at work with all the different parts of a cell, especially the energy engines, the mitochondria:-https://www.sciencedaily.com/releases/2016/09/160906131616.htm-"The respiratory chain is responsible for most energy production in humans. Several large protein assemblies are embedded in the mitochondrial lipid membrane. The mitochondrial Complex I is the first and largest complex in this chain. Metabolites derived from food are processed by this enzyme complex in order to contribute to the electron transfer and proton translocation. So far, research groups were only able to reveal mostly poly-alanine models lacking necessary full atomic details due to the fact that huge and complex molecules are difficult to examine with current methods. Cryo-electron microscopy made huge advances in recent years due to the development of new direct electron detectors, allowing high-resolution studies.-"The resolution of the structure at an atomic level now allows the understanding of the intricate arrangements and interactions of all 45 subunits (14 conserved core and 31 mitochondria-specific supernumerary subunits) with implications for the coupling mechanism and its regulation. The insight into mechanism, assembly, maturation, and dysfunction of Complex I allows a detailed molecular analysis of disease-causing mutations and affected enzyme activity."-Comment: See my initial statement, and be sure to look at the diagram. As techniques of resolution improve the complexity will only become more obvious and the odds of chance dwindle to nothingness. The research road ahead is clear, more and more complexity: chance has no chance of being the correct solution to the question of why is there life.