Introducing the brain: prewiring systems (Introduction)

by David Turell , Friday, August 16, 2024, 17:58 (31 days ago) @ dhw

In development before use:

https://www.sciencedaily.com/releases/2024/08/240815185851.htm

"In humans, the process of learning is driven by different groups of cells in the brain firing together. For instance, when the neurons associated with the process of recognizing a dog begin to fire in a coordinated manner in response to the cells that encode the features of a dog -- four legs, fur, a tail, etc. -- a young child will eventually be able to identify dogs going forward. But brain wiring begins before humans are born, before they have experiences or senses like sight to guide this cellular circuitry. How does that happen?

"In a new study published Aug. 15 in Science, Yale researchers identified how brain cells begin to coalesce into this wired network in early development before experience has a chance to shape the brain. It turns out that very early development follows the same rules as later development -- cells that fire together wire together. But rather than experience being the driving force, it's spontaneous cellular activity.

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"Previous research has shown that before sensory experience can take place -- for instance, when humans are in the womb or, in the days before young mice open their eyes -- spontaneously generated neuronal activity correlates and forms waves. In the new study, researchers found that when the activity of a single retinal ganglion cell was highly synchronized with waves of spontaneous activity in surrounding cells, the single cell's axon -- the part of the cell that connects to other cells -- grew new branches. When the activity was poorly synchronized, axon branches were instead eliminated.

"'That tells us that when these cells fire together, associations are strengthened," said Liang Liang, co-senior author of the study and an assistant professor of neuroscience at Yale School of Medicine. "The branching of axons allows more connections to be made between the retinal ganglion cell and the neurons sharing the synchronized activity in the superior colliculus circuit."

"This finding follows what's known as "Hebb's rule," an idea put forward by psychologist Donald Hebb in 1949; at that time Hebb proposed that when one cell repeatedly causes another cell to fire, the connections between the two are strengthened.

"'Hebb's rule is applied quite a lot in psychology to explain the brain basis of learning," said Crair, who is also the vice provost for research and a professor of ophthalmology and visual science. "Here we show that it also applies during early brain development with subcellular precision."

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"Spontaneous activity occurs during development in several other neural circuits, including in the spinal cord, hippocampus, and cochlea. While the specific pattern of cellular activity would be different in each of those areas, similar rules may govern how cellular wiring takes place in those circuits, said Crair."

Comment: the early brain is prewired to be prepared for the necessary complexification that comes with new learned experiences. This can only mean the design was made in anticipation of the new requirements. Only a thinking mind can design in anticipation of new requirements.