Introducing the brain: signals in both directions (Introduction)

by David Turell , Thursday, May 20, 2021, 19:38 (1070 days ago) @ David Turell

Some synapses are not one-way:

https://www.sciencealert.com/nerves-have-been-found-communicating-in-the-wrong-directio...

"The point at which our nerve cells meet to share information was thought to be a one-way street, with electrochemical signals strictly flowing from one neuron's sending axons to the next neuron's receiving dendrites.

"Now, for the first time, researchers have shown that information can also flow in the opposite direction at the neuron intersection we call a synapse.

"Once again, exact measurements have shown that reality is more complex than a simplified model would suggest," said cellular neuroscientist Peter Jonas from Austria's Institute of Science and Technology (IST).

***

"Within the hippocampus, the bit of our brains involved in memory and learning, is the mossy fiber pathway. This network of cells is crucial for storing short-term memory and has been shown in mice to be involved in spatial learning.

***

"As expected, the mossy neurons influenced the pyramidal neurons' signaling - but the researchers were surprised to find the reverse was true, too. (my bold)

"'The pre-synaptic mossy fiber detects when the post-synaptic neuron can't take more information: When activity increases in the post-synaptic neuron, the pre-synaptic neuron reduces the extent of plasticity," explains Jonas.

"This means there's a reverse-traveling signal from the dendrites of the pyramidal cell that in a complex way can modify the sending signal strength of the mossy neuron's axons. Challenging some long-standing assumptions, this confirms that the firing of synapses depends on both pre- and postsynaptic activity.

"'We find that this synapse acts like a 'smart teacher', who adapts the lessons when students are overloaded with information," said Jonas.

"They're not sure how the pyramid neuron sends its "I'm too full"' status update to the mossy neuron yet, but there are some clues, backed by previous research. Glutamate, the chemical messaging system used by neurons to DM each other, is a potential candidate.

"'Our results identify [glutamate receptors], probably activated by dendritically released glutamate, as the critical link between postsynaptic spiking activity and presynaptic terminal function," the researchers wrote in their paper.

"They suspect this modulating signal may be involved in optimizing information storage in our brains.

"'This might be a powerful mechanism to ensure that storage and recall are separated and that new information is preferentially stored in silent, non-coding pyramidal neurons," the team explained."

Comment: Note my bold and the surprise in the article at two-directional controls. Why do human guess at God's designs before they have the full story. It is like condemning the retina as backwards and upside down as a fault. We seem to guess wrong about God's works before we do the research.