Introducing the brain: neuron's very long lives (Introduction)

by David Turell , Monday, October 24, 2022, 17:09 (549 days ago) @ David Turell

Research shows the neurons have protective mechanisms:

https://medicalxpress.com/news/2022-10-born-survivehow-human-neurons-century.html

"Essentially all human tissues and organs have the capacity to heal, to renew cells which are damaged or killed. In this context, the human brain behaves fundamentally differently. The vast majority of nerve cells are created before birth and the regenerative capacity of the postnatal human brain is limited to a few regions.

"As a consequence, the average age of neurons in adults is much higher than that for any other cell type of the human body. But how do human neurons protect themselves from accidental cell death and maintain a high level of functionality throughout a human's lifespan?

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"They used human induced pluripotent stem cells (iPS cells) to generate human neurons in the culture dish which they matured over time, generating a developmental model of the brain where they could directly compare young, newborn neurons to their older, more mature counterparts. The study has now been published in the journal Cell Death & Disease.

"'If cells get stressed or harmed, they normally try to adopt to these conditions, by for instance activating reactive repair programs. At a certain degree of damage, a cell death program, called apoptosis, is activated to eliminate the harmed cell or tissue. This programmed cell death is controlled tightly by several molecular pathways," explains Prof. Philipp Koch, lead author of the study and Head of the HITBR. "We found that the threshold for entering cell death is particularly high in human neurons."

"Indeed, the researchers in Mannheim showed that once human neurons mature they get endowed with complex and redundant preemptive strategies to protect against stress and cell death.

"Among others, major components of the cell death machinery such as Caspases are strongly downregulated or shut off completely while protective pathways such as antiapoptotic Bcl-2 family proteins of inhibitors of apoptosis proteins (IAPs) are upregulated.

"'It seems that the brain developed a very elaborate, complex and complementary network to protect against cell death, likely an evolutionary adaptation to its reduced regenerative capacity. These safeguarding mechanisms in mature neurons may also in part explain why most neurodegenerative diseases are usually fend off for many decades and only tend to occur with advanced age. Manifestation of neurodegenerative diseases might be the result of many years of accumulated cell stress and damage in combination with a weakening of the maturity-dependent protective mechanisms," says Koch."

Comment: since our brain is in constant use, it is obvious neuron turnover, as in other organs, cannot happen. Cell division would disrupt thought