Introducing the brain: definine sex differences (Introduction)

by David Turell , Thursday, April 04, 2024, 20:33 (231 days ago) @ David Turell

A large study:

https://www.the-scientist.com/biological-sex-influences-brain-protein-expression-71763?...

"The findings, published in Nature Medicine, are a first step toward mechanistically understanding why some neurological conditions have pronounced sex-biases, which could guide improved treatments.1

"The team used donated post-mortem brain samples from individuals over the age of 60 with and without neurologic conditions. Using mass spectrometry, the researchers studied the proteome in six brain regions from more than 1,200 brains. After quality control analysis, the team evaluated just under 10,200 proteins for sex-based differences. More than 1,300 of these proteins exhibited different expression levels based on sex.

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"Because several brain conditions exhibit sex biases, the researchers compared the identified sex-biased proteins and their genes to gene-protein pairs that they previously associated with causal roles in a set of psychiatric, neurologic, or morphologic traits.2 The team identified 35 proteins from this group with sex-biased expression. Dalla noted that a strength of the present study was that it did not focus on a single disorder. “It really makes it unique that it manages to investigate so many different causal genes and proteins,” she said.

"Aliza Wingo explained that this is only the beginning for this work. “I believe that we can find more [sex-biased risk genes] when we have access to more sex-stratified genome wide association studies because, right now, those are limited,” she said, adding that more data could improve the design of therapeutic interventions.

"The team anticipates that factors such as the environment can influence brain protein expression between sexes, but they are excited about their current findings. “The fact that we are able to detect things that are changing or different between the brain that are relevant to these outcomes may start to help us understand why there’s prevalence differences for these traits,” said Thomas Wingo. “That’s an interesting new avenue to explore.'”

Comment: this shows how each different sex has a very different brain. What does that mean for the propaganda stating 'change your sex to whatever you wish/feel'?