Introducing the brain: questionable role of astrocytes (Introduction)

by David Turell , Wednesday, February 09, 2022, 20:42 (799 days ago) @ David Turell

More new findings:

https://medicalxpress.com/news/2022-02-star-like-brain-cells-unique-patterns.html

"The way people experience the world occurs due to complex and intricate interactions between neurons in the brain. Now, a study, published 9th February 2022 in Science Advances, suggests that astrocytes—star-shaped, non-neuronal cells in the brain—might also play an important role in processing information, and perhaps even memory.

"Using advanced imaging and analysis techniques, researchers from the Okinawa Institute of Science and Technology Graduate University (OIST) recorded signaling within single astrocytes at a previously unseen level of detail and speed in the brains of awake mice.

"Their findings, including ultra-fast signals on par with those seen in neurons and patterns of signaling activity that correspond to different behaviors, suggest that astrocytes may play a crucial role in many functions of our brain, including how we think, move, and learn.

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"...in recent years, there's been increasing amounts of evidence that astrocytes can listen to chemical messages sent between neurons at synapses, and can respond with their own signals, providing an extra layer of complexity to how our brain receives and responds to information.

"Still, the previously detected signals in astrocytes were about ten times slower than signals seen in neurons, with scientists therefore believing the cells were too slow for information processing.

"However, by developing a new toolkit that allows the study of astrocyte activity in awake mice with unprecedented detail, the researchers at OIST showed for the first time that astrocytes generate signals in vivo which are as fast as that of neurons, lasting fewer than 300 milliseconds.

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"The scientists then used an advanced computer program to analyze the recorded images, allowing them to detect the never-before-seen ultra-fast flashes of calcium signals, and evaluate signal patterns in an unbiased way.

"They found that sensory stimulation, by tickling the whiskers, resulted in very little calcium signaling, while certain behaviors, like running or walking, resulted in high levels of activity.

"The scientists also realized that there were certain areas in the astrocyte, or hotspots, where levels of activity were higher.

"'These hotspot maps are like fingerprints—for a specific behavior, they are stable over time, remaining the same over a period of days, and unique to each astrocyte," said Dr. Georgiou.

"Even more surprisingly, the team noticed that different behaviors corresponded to unique hotspot patterns.

"'So when the mouse is resting, you see one pattern. And then when the mouse is running, you see a different pattern," said Prof. Kuhn.

"One hypothesis suggested by Prof. Kuhn is that these hotspot maps could represent memory engrams—a pattern that represents a specific behavior or a memory. Different neuron networks are active during specific behaviors or when learning and recalling information, which could also change the activity of nearby astrocytes. Memory engrams are still theoretical, and highly controversial, he acknowledged.

"'We still don't know how memories are stored in a brain, but it's incredible to think that it could involve astrocytes," he said. "It's likely too good to be true, but it's an exciting hypothesis to follow up on.'"

Comment: one human failing is to assume too little. I fully believe everything we find in living material has a reason for its existence. Don't assumer anything until we can study it well. Remember the fiasco of 'junk' DNA.