Introducing the brain: cerebellum differs from mouse (Introduction)

by David Turell @, Saturday, October 19, 2019, 20:52 (339 days ago) @ David Turell

There are major differences in our brain from lesser animals:

"The work by the team involved very closely studying the development of the cerebellum in mice, humans and macaques—another animal that is used for cerebellum studies. After obtaining human cerebellum tissue samples from hospitals and other institutions, mouse samples from test mice and images of macaque cerebellum tissue from prior research efforts, the team compared them. They found they had enough material and data to compare cerebellum development from 30 days post-conception to approximately nine months after birth.

"The researchers report that they found a completely unexpected difference—a group of progenitor cells that had never before been seen in the human cerebellum or in the brains of either the mice or macaques. Until this finding, such cells had been seen only in the human cerebral cortex. They also found that some of the progenitor cells in an area called the rhombic lip were the source of cerebellar granule neurons. And they found that the rhombic lip took longer to develop in humans than the other two animals—it continued maturing throughout gestation. They suggest such clear differences could mean that comparison of the cerebellum across mice and humans may not be as revealing as has been hoped. They also note that such differences might also explain why it has been so difficult to mimic cerebellum-based human defects in animal models."

Comment: Our brain is really different from lesser organisms as this study shows.

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