Evolution: the newly-found bacterial gut role: (Evolution)

by David Turell , Wednesday, October 30, 2019, 22:01 (1849 days ago) @ David Turell

Each person has his own biome in his gut:

https://phys.org/news/2019-10-survive-human-gut-bacteria-genetic.html

"Bacteria living in people's intestines pump out toxins to deter microbial intruders. But each person's gut comes with its own set of toxins—an individualized "passcode" microbes must solve to survive, scientists report October 30, 2019, in the journal Nature.

"The findings suggest that there's not a one-size-fits-all approach to probiotics or live biotherapeutics, the microbial supplements that promote the growth of healthy bacteria, says study coauthor Joseph Mougous, a Howard Hughes Medical Institute (HHMI) Investigator

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{"The human gut is rife with bacteria. Feces contains about 100 billion bacterial cells per gram, and gut bacteria outnumber human cells 10 to 1. These microbes, collectively called the gut microbiome, take on all sorts of maintenance-type work, Mougous says. They digest food, keep the gut's surface intact, provide vitamins, and kick bad bacteria out. "The gut microbiome is very important for human health—that much we certainly know," he says.

"Over the last decade, Mougous's team has worked out the details of a bacterial defense mechanism called the type VI secretion system. It's like a molecular syringe that slams toxins into neighboring cells. The toxins break down cell walls, cleave membranes, and chew up cells' energy source. "They're pretty insidious," he says.

"Bacteria use immunity genes to neutralize these toxins and protect themselves. Invaders that lack the right genes get booted from the gut. Mougous's team had thought that toxin and immunity genes came together in pairs, like a lock and key. But an analysis of data from more than 1,000 human fecal samples revealed something surprising.

"Immunity genes from the gut bacteria Bacteroides fragilis vastly outnumbered toxin genes. All those extra immunity genes, the team discovered, actually belonged to other bacteria. Those bacteria had stolen B. fragilis's genes to protect themselves from its toxins. That means the genes must be crucial for bacteria to survive in the gut, Mougous says—something scientists hadn't known before.

"Mougous's team, including microbiologist Benjamin Ross, worked with UW's Elhanan Borenstein on the genomic analysis. Borenstein has since moved to Tel Aviv University, and Ross is now at Dartmouth College. "This collaboration was a lot of fun because it took both of our groups into new areas," Mougous says.

"Experiments in the lab showed that the immunity genes cluster together on stretches of DNA that can jump from bacterial strain to bacterial strain. In lab dishes and in living mice, bacteria given these genes immediately became resistant to B. fragilis's toxins.

"What's more, human fecal samples had unique combinations of toxin and immunity genes, the team found. "So what it takes to survive in one person's microbiome might not be the same in another person's microbiome," Mougous says."

Comment: Bacteria have been around ever since life started. Previous articles and this one show the important roles they still play. Start life and continue to help it.