Immunity system complexity: long term exhaustion (Introduction)

by David Turell , Saturday, February 01, 2025, 18:23 (35 days ago) @ David Turell

How T cells help in chronic illnesses:

https://www.sciencedaily.com/releases/2025/01/250131194428.htm

"...the study revealed that the endurance of these stem-like T cells is fuelled by a protein called ID3, expressed by a gene of the same name. These ID3+ T cells have a unique ability to self-renew and resist exhaustion, giving them the power to sustain immune responses far longer than other T cells that don't express ID3.

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"'ID3+ T cells have the remarkable ability to resist burnout and maintain a powerful immune response over time, making them particularly effective in the face of chronic infections or cancer," said and co-first author Gago da Graça.

The research also found that certain signals in the body could increase the number of ID3+ T cells, paving the way for improved treatments like CAR T cell therapy. While CAR T therapy has been transformative in treating certain cancers, its effectiveness can wane over time due to T cell exhaustion.

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"'We discovered that ID3+ T cell formation could be promoted by specific inflammatory cues, potentially offering new strategies to boost the number of immune cells that excel at fighting cancer in patients," said Professor Johnstone.

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"'Exhausted immune cells remain one of the biggest challenges in treating chronic diseases," said Dr Utzschneider.

"'This research provides a roadmap for how we might reinvigorate the immune system to improve health outcomes for people living with cancer or chronic infections like HIV or hepatitis B and C, thanks to these stem-like T cells, the immune system's secret power.'"

Comment: a necessary fighter in the immune system, allowing for a long term resistance. It demonstrates 'purpose' as do all evolutionary processes like it. It supports a designer theory.