Immunity system complexity: how malaria tricks it (Introduction)

by David Turell , Tuesday, October 27, 2020, 20:18 (1620 days ago) @ David Turell

Its all in the genes:

https://www.sciencenews.org/article/malaria-parasite-mosquitoes-genetics-immune-system

During Africa’s dry season, when mosquitoes are scarce, malaria parasites have a hard time spreading to new hosts. So the parasites hide out in the human body by keeping the cells they infect from clinging to blood vessels, researchers report October 26 in Nature Medicine. This way, infected cells get removed from circulation and parasite levels in the body remain low, making people less sick and allowing the parasite to persist undetected.

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Keeping a low profile during dry months is a successful strategy for the parasite, says Martin Rono, a parasitologist at the KEMRI-Wellcome Trust in Kilifi, Kenya, who was not involved in the work. Knowing how malaria parasites persist without causing disease, until mosquitoes return to ferry the organisms from an infected person to the next victim could help efforts to control malaria during the dry season.

Plasmodium falciparum, the parasite responsible for malaria, infects red blood cells as part of a complex life cycle. Once inside a cell, the parasite produces proteins that dock on the cell’s exterior and make it stick to blood vessels so that it won’t be carried to the spleen, where it would otherwise get removed from the body.

Typically, only the early life stages of the parasite circulate in the blood, while older parasites thrive inside red blood cells adhered to blood vessels, says Silvia Portugal, a biologist who led the work while at Heidelberg University Hospital in Germany. “That’s textbook, so it was very surprising” to see that dry-season parasites behaved differently in the lab, she says—the cells weren’t sticking.

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when the researchers compared which genes were turned on or off in samples taken from asymptomatic people in the dry season and symptomatic people in the wet season, they saw that 1,607 genes had distinct seasonal patterns. In the dry season, 1,131 genes were turned on that were off in wet-season parasites. Another 476 were turned off in dry-season parasites, suggesting that when the wet season ends, P. falciparum may alter its genetics to make red blood cells less sticky. That allows the parasite to replicate and persist without setting off alarm bells that alert the immune system to fight the infection.

Blood cells infected with malaria use certain proteins to adhere to blood vessels almost like Velcro, Portugal says. The loss of stickiness could be because the parasite makes fewer of these proteins, or because the proteins are different in some way.

Comment: Clever hide-out system with Plasmodium editing DNA just like Shapiro describes in bacteria. Did the two organisms share horizontal transfers of some sort? Malaria parasites can survive only if this system is in place from the beginning. Hard to imagine it happened through chance addition of bits and pieces. Leaves open the question of designed by God and back to theodicy we go.