Immunity system complexity: macrophage dual duties (Introduction)

by David Turell , Thursday, January 21, 2021, 20:32 (1534 days ago) @ David Turell

They attack and help healing:

https://phys.org/news/2021-01-closer-immune-cells.html

"Macrophages—immune cells that both fight infections and fix the damage they cause—are often placed into two categories: those that increase inflammation (known as "M1") to attack, and those that decrease inflammation to begin the healing process ("M2").

"Researchers in the lab of Kathryn Miller-Jensen, associate professor of biomedical engineering and molecular, cellular & developmental biology, used single-cell RNA sequencing to get a closer read on how individual macrophages react to different stimuli. They found that, while these cells tend to be multitaskers, some are more inclined toward responding to certain cues than others.

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"'No one had looked at that, and we decided to try it with single-cell sequencing," Miller-Jensen said. By doing so, the Miller-Jensen lab was able to get a much more detailed picture of macrophages' responses when stimulated with both inflammatory and resolving stimuli. They found a great deal of variability, including a subset of cells that seem to respond to only one cue or the other for certain key functions like secretion.

"'The stimuli are the environmental cues, but we're thinking that there might be some variability in the regulatory network inside the cells that allow some of them to respond more strongly to one cue versus another at any given time," Miller-Jensen said.

"It's an important step toward a better understanding of the different types of macrophages.

"'It could help us identify how macrophages exist in these different states in a tumor, or non-healing wounds, and other disease environments," she said. "If we had a more sophisticated understanding of what subsets exist, we might better figure out how to target them or regulate them."

"The researchers note that the diverse responses to opposing cues may allow macrophages to more readily adapt to changing environments, as well as to quickly transition from attack mode to focusing on tissue repair.

"'They might need to respond to a lot of cues at the same time, so a few of the macrophages might be primed to respond and be the attackers," she said. "So when they see both of those cues at the same time, it's important to have at least some of those cells to secrete what needs to be secreted—but maybe not all of those cells, because some may need to do something else.'"

Comment: Very clever design to have these cells multitask.