Genome complexity: dna repair mechanism (Introduction)

by David Turell , Friday, September 02, 2022, 20:32 (594 days ago) @ David Turell

A study of chromatin's role:

https://www.sciencedaily.com/releases/2022/09/220902122735.htm

"Researchers have discovered that the motion of chromatin, the material that DNA is made of, can help facilitate effective repair of DNA damage in the human nucleus -- a finding that could lead to improved cancer diagnosis and treatment.

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"DNA damage happens naturally in human body and most of the damage can be repaired by the cell itself. However, unsuccessful repair could lead to cancer.

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"Liu and his colleagues found that chromatin on the site of DNA damage moves much faster than those away from the DNA damage. They also found that the chromatin in cell nuclei is not moving randomly. It's a coherent movement, with the DNA moving as a group over a short distance.

"The researchers also found evidence that DNA damage may affect the DNA's group movement by reducing the coherence. These findings indicate that chromatin motion is under tight control when DNA is damaged. This is important to prevent the damaged DNA from harmful contact and to improve the accuracy and efficacy of DNA repair, Liu said.

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"In the future, the researchers hope to study single DNA molecules and how they are moving, and how individual and group dynamics differ and change in response to DNA damage. They'd also like to learn more about DNA movement in specific genes that are known to be more vulnerable to DNA damage."

Comment: it is obvious these DNA damage controls had to exist. Our knowledge is still incomplete, but our body's cells come with precise protective feedback loops and repair mechanisms at all levels of biological complexity way beyond what natural evolution could possibly produce. ID is correct.