Genome complexity: trading mitochondria is common (Introduction)

by David Turell , Friday, March 27, 2020, 22:09 (1490 days ago) @ David Turell

Latest paper finds this phenomenon is everywhere:

https://phys.org/news/2020-03-free-range-mitochondria.html

"Transfer of mitochondria between cells is a ubiquitously occurring and now universally known phenomenon. For years, researchers have been serially demonstrating that one particular new cell type can transfer its mitos to yet another particular cell type to achieve some specific metabolic goal essential to survival of the meta-host organism. But what happens when the mitochondria come from the outside world, from other members of your own species, or from a different species altogether? In addressing this very real situation, we first must look at the particulars of how and why mitos are transmitted across cell boundaries in the first place.

"One of the latest dispatches,... describes a curious situation in which mesenchymal stem cells (MSCs) transfer mitos directly to T cells in order to tamp down an overactive immune system and curb an inflammatory response. More specifically, the Chilean authors report that mito uptake by CD+ T cells induces regulatory T cell differentiation and activation through increased expression of FOXP3, IL2RA, CTLA4, and TGFb mRNAs. Mesenchymal stem cell transfer had been well established in earlier disease models of acute respiratory distress (ARDs), in which transfer to macrophages through tunneling nanotubes upregulates their phagocytic capability.

***

"The key is understanding how the mitos actually travel. In other words, what are the mitochondrial circuits? Many clues have recently emerged, including what mitos are capable of doing when they cycle through the master of all networks—the nervous system. The one-way travel to macrophages described above does not necessarily end there. Macrophages can, in turn, donate their mitos directly to nerve endings in times of need. Once there, they can do some incredible things. For example, in sensory neurons of the DRG (dorsal root ganglion) mitos ultimately derived from M2 macrophages turn off the inflammation response and completely resolve the associated pain messaging. This leg of the circuit requires expression of CD200 Receptor (CD200R) on macrophages and the non canonical CD200R-ligand iSec1 on sensory neurons.

"Perhaps even more intriguingly, these mitos also have a side-hussle—they
briefly sojorn as free range mitochondria in whole blood. During these sabbaticals, they persist entirely cell free, but still respiratory competent mitochondria. What this essentially means is that when we donate and receive blood or bone, we are also exchanging not just mitochondria, but also in a very real genetic sense, our identities—at least as defined within the limits of current forensic testing of this mosaic-chimeric state. No one should be all that surprised, because our species is also on the cusp of being actively engaged in a subtle but perhaps more insidious trans-species mitochondrial migration through organ transplant."

Comment: Mitochondrias are as free-ranging as Margulis might have imagined when she proposed her theory. They must play some sort of a role in speciation. This article is actually about using them in therapy.