Genome complexity: rapid cellular transcriptions (Introduction)

by David Turell , Sunday, November 07, 2021, 20:02 (894 days ago) @ David Turell

High speed reaction times in setting up transcription machinery:

https://www.sciencedaily.com/releases/2021/11/211105134631.htm

"It is essential for cells to control precisely which of the many genes of their genetic material they use. This is done in so-called transcription factories, molecular clusters in the nucleus. Researchers have now found that the formation of transcription factories resembles the condensation of liquids. Their findings will improve the understanding of causes of diseases and advance the development of DNA-based data storage systems.

"It is essential for cells to control precisely which of the many genes of their genetic material they use. This is done in so-called transcription factories, molecular clusters in the nucleus. Researchers of Karlsruhe Institute of Technology (KIT), Friedrich-Alexander-Universität Erlangen-Nuremberg (FAU), and Max Planck Center for Physics and Medicine (MPZPM) have now found that the formation of transcription factories resembles the condensation of liquids.

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"Human genetic material contains more than 20,000 different genes. But each cell only uses a fraction of the information stored in this genome. Hence, cells have to control precisely which genes they use. If not, cancer or embryonal growth disorder may develop. So-called transcription factories play a central role in the selection of active genes. "These factories are molecular clusters in the nucleus that combine the correct selection of active genes and the read-out of their sequence at a central location," Lennart Hilbert explains.

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"In their publication, the researchers point out that condensation to form transcription factories resembles steamy glasses or windows. Liquid condenses in the presence of a receptive surface only, but then very quickly. In the living cell, specially marked areas of the genome are used as condensation surfaces. The liquid-coated areas allow for the adhesion of relevant gene sequences and additional molecules that eventually activate the adhering genes. These findings were obtained by interdisciplinary cooperation.

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"'Our work shows how the biological cell organizes such processes rapidly and reliably.'"

Comment: Same old story. Transcription processes are extremely rapid and accurate, but as discussed in the theodicy thread, mistakes by rapidly changing molecules can happen occasionally. God added editing systems to correct these as much as they could.