Genome complexity: packing DNA in different ways: (Introduction)

by David Turell , Saturday, June 12, 2021, 21:23 (1048 days ago) @ David Turell

Many species have two different ways of doing it:

https://www.sciencenews.org/article/cells-nucleus-dna-chromosomes-genome-organization

"There appear to be two methods to stuff all of that DNA in, researchers report in the May 28 Science. Cells can even flip-flop which arrangement they have by inactivating a molecule called condensin II, the team found.

"If chromosomes were pieces of paper, some, like those of humans, would look like a crumpled ball inside the nucleus, says Claire Hoencamp, a molecular biologist at the Netherlands Cancer Institute in Amsterdam (SN: 10/8/09). Others, like those of fruit flies (Drosophila melanogaster), resemble flat sheets of stacked paper.

"Throughout evolutionary history, organisms across the tree of life have switched among different packing methods, the researchers found. “We worked with a zoo of species, and [at first] it looked like a zoo of patterns of genome folding,” Dudchenko says. “Some maps would look like a checkerboard pattern. Other ones would look like a mattress with weird x’s.” Over time, it became clear that many of the same chromosome folding features were popping up again and again in different species.

"Three types of interactions result in stacked sheets of chromosomes, giving the heat maps that checkerboard or mattress look. In one interaction, seen in the ground peanut (Arachis hypogaea) for example, the ends of different chromosomes tend to touch. In another, chromosomes from organisms like fruit flies touch in the middle. And in an interaction seen in bread wheat (Triticum aestivum), the arms of different chromosomes fold on top of one another.

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"Breaking parts of condensin II — a complex of proteins that helps assemble chromosomes as cells divide — can switch which organization a nucleus has. Tweaks to condensin II can make a crumpled human nucleus look like a folded fly’s nucleus, the team found. But some organisms have stacked sheets despite having intact condensin II. That means there may be other factors researchers haven’t yet found that push cells to cram chromosomes into the nucleus in a specific way, Hoencamp says."

Comment: This is just a new fact with more needed to come. It is not clear why DNA has to be packed in two different way. What is clear is that cells can still split no matter how the DNA is arranged.