Genome complexity: chromotin motion in cell disivion (Introduction)

by David Turell , Friday, June 03, 2022, 20:05 (693 days ago) @ David Turell

Aids in protection DNA from problems:

https://phys.org/news/2022-06-dna-steadily-interphase-cells-robust.html

"Researchers in Japan have discovered that the local DNA motion inside of human cells remains steady throughout interphase, where the cell grows and replicates its DNA for cell division. The study suggests that this steady-state DNA motion allows cells to conduct housekeeping tasks under similar environments during interphase.

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"Maeshima and colleagues have revealed that the local chromatin motion remains steady throughout interphase, although genome DNA is doubled by DNA replication and the nucleus grows. The researchers also have shown that nuclear growth without replication did not affect the steady-state motion of chromatin. Thus, local chromatin motion is independent of such nuclear changes during interphase.

"'This is an important finding because the steady-state motion allows cells to conduct their routines, such as RNA transcription and DNA replication, under similar nuclear environments," the first author Shiori Iida said. "Local chromatin motion can govern genomic DNA accessibility for target searching or recruiting a piece of machinery. The steady-state motion of chromatin provides a robust cellular system in which DNA functions are unaffected by various nuclear changes."

"'Cells can transiently change the chromatin motion from the steady state to perform their ad hoc jobs in response to DNA damages, among many other tasks," Maeshima said. He and his team aim to further explore how DNA motion is regulated, which proteins are involved in the regulation process, and how DNA behaves during cell division. "Our ultimate goal is to understand how human genomic DNA inside the cell behaves to read-out genetic information in it," Maeshima said."

Comment: an irreducibly complex system for DNA protection from errors whikle undergoing cell division. Must be designed all at once.