Genome complexity: DNA repair enzyme decoded (Introduction)

by David Turell @, Friday, December 11, 2015, 19:11 (1378 days ago) @ David Turell

The structure of this massive enzyme made up of thousands of amino acids is now pictured:

"An enzyme crucial to the process of DNA repair in our cells has been mapped in atomic detail by researchers at the University of Dundee, the UK's top-rated University for Biological Sciences.

"DNA repair plays a key role in human diseases such as cancer. Researchers say that revealing the 3D molecular structure of a key enzyme involved in this process could be an important step towards developing future drugs.

"DNA is the genetic `library' of the cell and is so important that it must be repaired when damaged. It is the only kind of molecule in the cell that is subject to such repair. In one such process, DNA temporarily forms interconnections, called junctions, that much be processed by special enzymes, including one called GEN1, which has now been mapped by the Dundee team.

"'GEN1 was the first of these proteins to be identified, and only relatively recently," said Professor David Lilley, from the School of Life Sciences at the University of Dundee, who has led this new work.

"'We have now determined the molecular structure of GEN1 in fine detail. This is an important step towards understanding DNA repair and how we may be able to develop drugs in future."

Comment: Usual point. How did this complex molecule develop through chance evolution. It is absolutely required to protect DNA from mistakes in cell division, and it had to appear when DNA appeared. Only design fits.

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