Magic embryology: tight controls, including death (Introduction)

by David Turell , Wednesday, June 15, 2022, 23:37 (680 days ago) @ David Turell

When cells wander off course they self-distruct:

https://phys.org/news/2022-06-cells-self-destruct.html

"The new research identifies the mechanisms that ensure that any wayward, wandering cells will self-destruct through a specific form of cell death called anoikis. Interestingly, resistance to anoikis is a precursor to many types of metastatic cancers. Understanding the pathways that guide healthy anoikis may ultimately provide insight into how cancers metastasize and why they invade certain parts of the body.

"'Cell death is a normal, healthy part of development," Stathopoulos says. "The migrating cell has to constantly be making decisions and figuring out if it is in the in the right place in the body. If it's not in the right place, it needs to self-destruct. We have now determined the pathways through which the cell can do this."

***

"The CVM cells do not make their long journey through the fruit fly embryo alone. These 40 to 50 cells follow a kind of track that is made up of a different cell type called trunk visceral mesoderm (TVM). TVM cells emit a chemical signal called fibroblast growth factor (FGF), which lets a CVM cell know that it is in the right place.

"At the midpoint of their migration, the CVM cells must navigate around a sharp bend in the embryo, which is roughly U-shaped. At this juncture, CVM cells start proliferating in anticipation of soon being at the end of their journey, when it will be time to start building muscle. The problem is, when cells start multiplying, some begin to drift off of the TVM track. Researchers have previously observed that this is the point where these lost cells will undergo anoikis and self-destruct.

"A gene called hid (short for head involution defective) is responsible for anoikis. When hid is expressed in a cell, the cell will die. In the new work, Macabenta found that CVM cells begin to express hid as they make the turn around the bend in the embryo, but they do not die—unless they fall off of the TVM track.

"The team found that this is possible thanks to the FGF signals, which act as the antidote to hid: If a cell falls off of the track and therefore stops receiving FGF signals, it will die; it can stay alive despite hid being expressed as long as it stays on track. In this way, the embryo can make sure that any wayward cells will self-destruct, while properly functioning cells are spared.

"Finally, the team also discovered that a particular pathway, called the bone morphogenetic protein (BMP) pathway, controls the timing of when the cells begin to proliferate. BMP signaling initiates just as cells navigate the U-shaped turn, roughly at the midpoint of their migration. It is this signal that allows cells to divide and grow in number.

"Cells have an internal "clock," known as the cell cycle, which controls the timing of growth, DNA replication, and cell division (mitosis). The team found that the timing of hid expression is linked to progression of the cell cycle, and when this is disrupted, hid is no longer expressed at the right point during cell migration. BMP signaling is necessary to allow the cell cycle to move forward through mitosis and is therefore also necessary for timing the precise expression of hid, as cells that fail to divide are not able to express hid in a timely manner to eliminate lost cells.

It is crucial that cells are able to have these programmed quality control mechanisms because wayward cells can be damaging to the proper development of the rest of the organism.
(My bold)

Comment: As embryos develop, cells must follow precise paths directed by precise signals, in order to end up as duplicate copies of parents. Here we see nothing but guide signals. It cannot be like herding cats. This shows how cells can operate fully by chemical signals in all cellular operations incuding epigenetics. The Speciation mechanism is totally unknown