Magic embryology: signals that connect neurons (Introduction)

by David Turell @, Monday, December 23, 2019, 19:08 (961 days ago) @ David Turell

Neurons send branches to many other neurons to make the interpretive networks. Chemical signals are used:

"The brain's complex tangle of interconnected nerve cells processes visual images, recalls memories, controls motor function, and coordinates countless other functions. A major goal of neuroscience is understanding how the brain is "wired"—in other words, how do all of its neurons know how they should connect to each other to achieve optimum function?

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"In the 1960s, Caltech neuroscientist and Nobel Laureate Roger Sperry proposed that neural circuit assembly is guided by interactions between cell-surface proteins—proteins that sit on the outer surface of neurons and other cells. Sperry's hypothesis, which was based on his experiments on optic pathways in frog and fish brains, was that these proteins act like signposts, labeling individual neurons in the brain as appropriate targets for neurons in the eye. The new work from the Zinn laboratory identifies brain and eye cell-surface proteins in Drosophila that have these signpost functions.

"Several years ago, researchers at Stanford and in the Zinn group at Caltech expressed each of 200 different Drosophila cell-surface proteins in lab dishes and characterized all the binding reactions among these proteins that occur in a test tube (about 40,000 possible combinations).

"The work revealed that two families of cell-surface proteins, dubbed Dprs and DIPs, have a particular affinity for one another and that members of both families are found on the surfaces of neurons. Researchers in the Zinn laboratory have been trying to understand how this interaction plays a role in neural development.

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"They found that, when neural connections are being made in the developing visual system, the target neurons are generated in excess and compete for their photoreceptor partners. This matching is possible because of the interaction between Dpr11 on the photoreceptors and DIP-gamma on the target neurons. Thus, if the two proteins were not both expressed (as was the case, for example, in flies with mutations in either the dpr11 or DIP-gamma genes), the target neurons died and the neural circuit did not develop correctly. Analysis of the neural connections in mutant flies suggests that they should have defects in color vision.

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"Though the researchers have discovered that this specific Dpr/DIP pairing is critical for proper neural-circuit formation, any given neuron expresses about 250 different cell-surface proteins, making the analysis of how cell-surface proteins control connectivity very complex. Future work will continue to study how synaptic connectivity is determined by pairings between Dprs and DIPs and other cell-surface proteins, with the ultimate goal of understanding the information required to create the entire wiring diagram of the fly brain."

Comment: Another complex arrangement to guide development of neuronal connections, all pre-planned by instructions that produce these specific protein signals and make each new brain about the same. There must be an underlying plan to be followed. this cannot be designed by chance.


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