Magic embryology: managing DNA/chromosomes (Introduction)

by David Turell @, Saturday, February 29, 2020, 23:16 (851 days ago) @ David Turell

They are purposely handled in a 3-D manner:

"The spatial arrangement of genetic material within the cell nucleus plays an important role in the development of an organism.


" The reason why cells develop differently is that only parts of their chromosomes are read. This results in some genes being active while others, in contrast, are silent.

For gene activation, both the way the genes are packaged as well as their spatial organization in the cell nucleus play a decisive role.


"...chromosome domains segregated into two compartments, active and inactive. "During early embryogenesis, however, the chromosomes are organized differently," says Ahilya Sawh, first author of the study. "In the early embryo, they are organized into an unconventional barbell-like structure, with inactive compartments separated by a central active region." The researchers discovered that the nuclear lamina—a protein mesh lining the inner surface of the cell nucleus—is required to achieve this barbell arrangement. The lamina is attached to the inactive sections and stretches the chromosome.

"'Only at a later stage of embryonic development, when the germ layers develop, we actually see the well-known segregation into an active and inactive region," explains Mango. "Using chromosome tracing, we were able to map the whole 3-D chromosome architecture and could show for the first time that chromosomes rearrange during early development, a maturation process that requires the nuclear lamina."

"The reorganization of the chromosomes accompanies cell maturation and represents a milestone in the development of a complex organism. The correct chromosomal architecture is crucial to prevent developmental disorders."

Comment: This kind of 3-D control is a highly designed mechanism. It cannot be developed by chance. That is the choice: chance or design by a designer.

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