Magic embryology: egg sends protein signal to guide sperm (Introduction)

by David Turell , Saturday, August 04, 2018, 23:07 (2303 days ago) @ David Turell

That signal has finally been found:

https://phys.org/news/2018-08-scientists-elusive-molecule-sperm-egg.html

"More than 100 years ago, MBL Director F.R. Lillie of the University of Chicago discovered that eggs from marine invertebrates release a chemical factor that attracts sperm, a process called chemotaxis. Sperm, for their part, swim up a chemical gradient to reach the egg, assisted by a pulsatile rise in calcium ion (Ca2+) concentration in the sperm tail that controls its beating.

"In past years, many of the cellular components that translate chemoattractant stimulation into a Ca2+ response have been revealed, but a crucial ingredient has been missing. A prerequisite for Ca2+ ions from the sperm's environment being able to enter the tail is that the sperm cell's pH becomes more alkaline. The molecule that brings about this change in pH has been elusive.

"In this new report, U. Benjamin Kaupp, a MBL Whitman Center Scientist from the Center of Advanced European Studies (Caesar) in Bonn, Germany, identifies this molecule. Kaupp spent 18 summers at the MBL conducting research in the footsteps of F.R. Lillie's original quest.

***

"The molecule that Kaupp and colleagues identified allows sodium ions to flow into the sperm cell and, in exchange, transports protons out of the cell. Such so-called sodium/proton exchangers have been known for a long time, but this one is special. It is a chimaera that shares structural features with ion channels, called pacemaker channels, which control our heartbeat and electrical activity in the brain.

"This sodium/proton exchange in the sperm cell, like in the pacemaker channels, is activated by a stretch of positively charged amino acids called the voltage sensor. When sperm capture chemoattractant molecules, the voltage becomes more negative, because potassium channels open and potassium ions leave the cell. The voltage-sensor registers this voltage change and the exchanger begins exporting protons from the cell; the cell's interior becomes more alkaline. When this mechanism is disabled, the Ca2+ pulses in the sperm tail are suppressed, and sperm are lost on their voyage to the egg. "

Comment: this article shows the complexity that sexual reproduction requires. How did it happen when early life had the simpler process of splitting single cells, although that process is itself very complex? This supports the concept that evolution contains a complexification mechanism as a driving force.