Magic embryology: more junk has function (Introduction)

by David Turell , Tuesday, September 18, 2018, 18:09 (2046 days ago) @ David Turell

Darwinists consider transposons as junk. It isn't:

https://phys.org/news/2018-09-genes-deletion-genome.html

"Transposons are pieces of DNA that move around in the genome, transported by enzymes called transposases that bind to them. As transposons jump around during evolution, host organisms can acquire the genes they carry and use them to gain new functions in a process known as domestication.

"Transposases from a family called PiggyBac have repeatedly been domesticated in various organisms. Although their function is poorly understood, they are known to play an essential role in the reproduction of ciliates, such as Paramecium.

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"'We knew that PiggyMac, a domesticated transposase in the PiggyBac family, was responsible for cleaving the DNA, but what we didn't know is exactly how the removal machinery is accurately positioned at the ends of this DNA," explains lead author Julien Bischerour, researcher at the Institute for Integrative Biology of the Cell, CNRS, University of Paris-Saclay, France.

"In this study, the team identified five further groups of the PiggyBac family of transposases that work together with PiggyMac to accurately delete specific pieces of DNA in the Paramecium genome. By silencing the different domesticated PiggyBac transposases, they found that each group plays an architectural role and is essential for the movement of PiggyMac to the cell nucleus during reproduction and subsequent gene removal.

"Moreover, blocking the activity of the PiggyBac transposases caused a number of errors in the removal process. This showed that some family members retained activity, but the process became less efficient and accurate. It also revealed insights into the preferred lengths of DNA cleaved by these molecules. The fact that some sequences were mechanistically difficult to remove shed new light on potential constraints on gene deletion in Paramecium during evolution.

"'Our discovery of novel PiggyMac partners, coded by five groups of duplicated genes in the Paramecium genome, brings new insight into the removal mechanism of these non-coding sequences by transposases and deeper understanding of the machinery involved," explains senior author Mireille Bétermier, researcher at the Institute for Integrative Biology of the Cell, CNRS, University of Paris-Saclay. "Based on our work, future investigations into human domesticated transposases should take into consideration the possibility that these molecules may be involved together in the same cellular function.'"

Comment: More function found for transposions which have been considered part of non-coding 'junk' DNA by Darwinists.