Magic embryology: microglia help prune synapses (Introduction)
by David Turell 
, Saturday, August 28, 2021, 14:44 (1184 days ago) @ David Turell
Study in mouse young brains:
https://science.sciencemag.org/content/373/6558/978.2?utm_campaign=ec_sci_2021-08-26&am...
"A fundamental question in developmental neuroscience is how different cell types wire together with exquisite specificity to ensure the formation of canonical neural circuits. Increasingly, non-neural cells have been implicated as being essential to this process. Microglia-resident immune cells of the brain play crucial roles in refining synaptic connections. Favuzzi et al. show that GABA-receptive microglia interact with inhibitory synapses in developing mice 2 to 3 weeks after birth. Within this population of microglia, GABA promotes the selective pruning of inhibitory connectivity. Perturbing these specialized microglia caused long-lasting defects in inhibitory connectivity without affecting excitatory synapses and led to hyperactivity in adult animals. Thus, distinct microglial populations differentially engage with specific synapse types during development to modulate behavior."
Comment: I view embryology occurring after birth, just as in human development for years after birth. This precise arrangement with cooperating microglia tailoring synapses must have a designer. Not by chance.
Complete thread:
- Magic embryology -
David Turell,
2013-06-04, 15:22
![[*]](themes/default/images/complete_thread.png "Open whole thread")
- Magic embryology:extensive programming on display -
David Turell,
2017-12-13, 18:28
- Magic embryology:extensive programming on display -
David Turell,
2018-01-21, 21:32
- Magic embryology:extensive programming on display -
dhw,
2018-01-22, 14:30
- Magic embryology:extensive programming on display -
David Turell,
2018-01-22, 15:00
- Magic embryology:extensive programming on display -
dhw,
2018-01-23, 12:52
- Magic embryology:extensive programming on display -
David Turell,
2018-01-23, 14:50
- Magic embryology:extensive programming on display -
dhw,
2018-01-24, 13:57
- Magic embryology:extensive programming on display -
David Turell,
2018-01-24, 15:17
- Magic embryology:extensive programming on display -
dhw,
2018-01-26, 13:31
- Magic embryology:extensive programming on display -
David Turell,
2018-01-27, 00:22
- Magic embryology:extensive programming on display -
dhw,
2018-01-27, 13:22
- Magic embryology:extensive programming on display -
David Turell,
2018-01-27, 14:55
- Magic embryology: forming fetus totally unexplained -
David Turell,
2018-01-27, 21:33
- Magic embryology: forming fetus totally unexplained -
David Turell,
2018-04-16, 00:50
- Magic embryology: forming a blastocyst envelope: -
David Turell,
2018-08-01, 23:01
- Magic embryology: seed to plant needs complex steps -
David Turell,
2018-08-02, 22:12
- Magic embryology: egg sends protein signal to guide sperm -
David Turell,
2018-08-04, 23:07
- Magic embryology: physical forces form organs -
David Turell,
2018-09-05, 21:04
- Magic embryology: physical forces form organs -
Balance_Maintained,
2018-09-06, 04:05
- Magic embryology: physical forces form organs -
David Turell,
2018-09-06, 14:00
- Magic embryology: physical forces form organs -
dhw,
2018-09-10, 09:38
- Magic embryology: physical forces form organs -
Balance_Maintained,
2018-09-10, 17:15
- Magic embryology: physical forces form organs - David Turell, 2018-09-10, 21:41
- Magic embryology: physical forces form organs -
David Turell,
2018-09-10, 21:33
- Magic embryology: physical forces form organs -
dhw,
2018-09-11, 13:15
- Magic embryology: physical forces form organs -
David Turell,
2018-09-11, 14:02
- Magic embryology: physical forces form organs -
dhw,
2018-09-12, 09:00
- Magic embryology: physical forces form organs -
David Turell,
2018-09-12, 14:48
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-17, 21:14
- Magic embryology: placenta maintains symmetry -
Balance_Maintained,
2018-09-18, 00:42
- Magic embryology: placenta maintains symmetry -
dhw,
2018-09-18, 13:33
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-18, 15:28
- Magic embryology: more junk has function - David Turell, 2018-09-18, 18:09
- Magic embryology: placenta maintains symmetry -
dhw,
2018-09-19, 10:09
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-19, 15:00
- Magic embryology: placenta maintains symmetry -
dhw,
2018-09-20, 12:12
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-20, 18:01
- Magic embryology: placenta maintains symmetry -
dhw,
2018-09-21, 15:31
- Magic embryology: placenta maintains symmetry -
Balance_Maintained,
2018-09-21, 20:18
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-21, 21:00
- Magic embryology: placenta maintains symmetry -
Balance_Maintained,
2018-09-22, 00:21
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-22, 15:51
- Magic embryology: placenta invades Mother -
David Turell,
2018-12-04, 15:18
- Magic embryology: placental role in diet and oxygen -
David Turell,
2019-01-19, 20:03
- Magic embryology: placental role in diet and oxygen -
dhw,
2019-01-20, 12:30
- Magic embryology: information and instructions -
David Turell,
2019-01-28, 23:07
- Magic embryology: growing mouse kidney in rats -
David Turell,
2019-02-05, 18:03
- Magic embryology: special macrophages thin heart valves -
David Turell,
2019-02-24, 01:47
- Magic embryology: special chemicals used to signal - David Turell, 2019-03-03, 01:28
- Magic embryology: special macrophages thin heart valves -
David Turell,
2019-02-24, 01:47
- Magic embryology: growing mouse kidney in rats -
David Turell,
2019-02-05, 18:03
- Magic embryology: information and instructions -
David Turell,
2019-01-28, 23:07
- Magic embryology: placental role in pregnancy -
David Turell,
2020-02-05, 22:40
- Magic embryology: placental forms before embryo - David Turell, 2020-09-24, 20:39
- Magic embryology: placental role in diet and oxygen -
dhw,
2019-01-20, 12:30
- Magic embryology: placental role in diet and oxygen -
David Turell,
2019-01-19, 20:03
- Magic embryology: placenta invades Mother -
David Turell,
2018-12-04, 15:18
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-22, 15:51
- Magic embryology: placenta maintains symmetry -
Balance_Maintained,
2018-09-22, 00:21
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-21, 21:00
- Magic embryology: placenta maintains symmetry - David Turell, 2018-09-21, 20:36
- Magic embryology: placenta maintains symmetry -
Balance_Maintained,
2018-09-21, 20:18
- Magic embryology: placenta maintains symmetry -
dhw,
2018-09-21, 15:31
- Magic embryology: placenta maintains symmetry - Balance_Maintained, 2018-09-20, 22:35
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-20, 18:01
- Magic embryology: placenta maintains symmetry -
dhw,
2018-09-20, 12:12
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-19, 15:00
- Magic embryology: placenta maintains symmetry -
Balance_Maintained,
2018-09-19, 05:14
- Magic embryology: it is all in the timing -
David Turell,
2018-10-19, 20:51
- Magic embryology: tight controls, including death -
David Turell,
2022-06-15, 23:37
- Magic embryology: both genes and physical forces - David Turell, 2022-07-13, 21:52
- Magic embryology: tight controls, including death -
David Turell,
2022-06-15, 23:37
- Magic embryology: What guides cell development, placement? -
David Turell,
2019-03-15, 01:12
- Magic embryology: What guides nerve pathways to muscles? -
David Turell,
2019-03-23, 17:48
- Magic embryology: guiding body orientation - David Turell, 2019-05-19, 18:55
- Magic embryology: What guides cell development, placement? -
David Turell,
2019-08-12, 17:42
- Magic embryology: What guides limbs? electric patterns -
David Turell,
2019-10-08, 05:08
- Magic embryology: developing an immune and blood systems -
David Turell,
2019-10-09, 18:32
- Magic embryology: developing brain neuron clusters -
David Turell,
2019-10-09, 18:48
- Magic embryology: how stem cells follow genetic instructions -
David Turell,
2019-11-08, 19:36
- Magic embryology: little understood -
David Turell,
2019-12-09, 15:38
- Magic embryology: video egg to organism in 6 minutes -
David Turell,
2019-12-23, 15:01
- Magic embryology: signals that connect neurons -
David Turell,
2019-12-23, 19:08
- Magic embryology: rules for growing a new fetus -
David Turell,
2020-01-21, 22:14
- Magic embryology: rules for growing a new fetus -
dhw,
2020-01-22, 14:35
- Magic embryology: rules for growing a new fetus -
David Turell,
2020-01-22, 16:27
- Magic embryology: rules for growing a new fetus -
dhw,
2020-01-23, 10:01
- Magic embryology: rules for growing a new fetus -
David Turell,
2020-01-23, 22:34
- Magic embryology: rules for growing a new fetus -
dhw,
2020-01-24, 11:41
- Magic embryology: rules for growing a new fetus -
David Turell,
2020-01-24, 20:39
- Magic embryology: requires exact timing for every tissue -
David Turell,
2020-02-05, 16:55
- Magic embryology: requires exact timing for every tissue -
dhw,
2020-02-06, 14:36
- Magic embryology: requires exact timing for every tissue -
David Turell,
2020-02-07, 01:27
- Magic embryology: requires exact timing for every tissue -
dhw,
2020-02-07, 13:09
- Magic embryology: requires exact timing for every tissue -
David Turell,
2020-02-07, 21:23
- Magic embryology: requires exact timing for every tissue -
dhw,
2020-02-08, 15:28
- Magic embryology: requires exact timing for every tissue -
David Turell,
2020-02-08, 18:59
- Magic embryology: managing DNA/chromosomes -
David Turell,
2020-02-29, 23:16
- Magic embryology: rapid stem cell differentiation -
David Turell,
2020-04-19, 22:58
- Magic embryology: rapid stem cell differentiation -
dhw,
2020-04-20, 15:19
- Magic embryology: rapid stem cell differentiation -
David Turell,
2020-04-20, 16:15
- Magic embryology: rapid stem cell differentiation -
dhw,
2020-04-21, 13:08
- Magic embryology: rapid stem cell differentiation -
David Turell,
2020-04-21, 19:24
- Magic embryology: rapid stem cell differentiation -
dhw,
2020-04-22, 11:47
- Magic embryology: rapid stem cell differentiation -
David Turell,
2020-04-22, 23:22
- Magic embryology: guiding limb formation -
David Turell,
2020-06-03, 21:51
- Magic embryology: epigenetic controls - David Turell, 2020-08-04, 21:37
- Magic embryology: guiding limb formation -
David Turell,
2020-06-03, 21:51
- Magic embryology: rapid stem cell differentiation -
David Turell,
2020-04-22, 23:22
- Magic embryology: rapid stem cell differentiation -
dhw,
2020-04-22, 11:47
- Magic embryology: rapid stem cell differentiation -
David Turell,
2020-04-21, 19:24
- Magic embryology: rapid stem cell differentiation -
dhw,
2020-04-21, 13:08
- Magic embryology: rapid stem cell differentiation -
David Turell,
2020-04-20, 16:15
- Magic embryology: rapid stem cell differentiation -
dhw,
2020-04-20, 15:19
- Magic embryology: rapid stem cell differentiation -
David Turell,
2020-04-19, 22:58
- Magic embryology: managing DNA/chromosomes -
David Turell,
2020-02-29, 23:16
- Magic embryology: requires exact timing for every tissue -
David Turell,
2020-02-08, 18:59
- Magic embryology: requires exact timing for every tissue -
dhw,
2020-02-08, 15:28
- Magic embryology: requires exact timing for every tissue -
David Turell,
2020-02-07, 21:23
- Magic embryology: constantly influenced by the biome -
David Turell,
2020-08-27, 19:11
- Magic embryology: human segmentation is lower -
David Turell,
2020-09-17, 20:35
- Magic embryology: human development is slower - David Turell, 2020-09-19, 18:21
- Magic embryology: human segmentation is lower -
David Turell,
2020-09-17, 20:35
- Magic embryology: mechanical forces reviewed - David Turell, 2021-01-13, 19:07
- Magic embryology: requires exact timing for every tissue -
dhw,
2020-02-07, 13:09
- Magic embryology: requires exact timing for every tissue -
David Turell,
2020-02-07, 01:27
- Magic embryology: requires exact timing for every tissue -
dhw,
2020-02-06, 14:36
- Magic embryology: requires exact timing for every tissue -
David Turell,
2020-02-05, 16:55
- Magic embryology: rules for growing a new fetus -
David Turell,
2020-01-24, 20:39
- Magic embryology: rules for growing a new fetus -
dhw,
2020-01-24, 11:41
- Magic embryology: rules for growing a new fetus -
David Turell,
2020-01-23, 22:34
- Magic embryology: rules for growing a new fetus -
dhw,
2020-01-23, 10:01
- Magic embryology: rules for growing a new fetus -
David Turell,
2020-01-22, 16:27
- Magic embryology: rules for growing a new fetus -
dhw,
2020-01-22, 14:35
- Magic embryology: rules for growing a new fetus -
David Turell,
2020-01-21, 22:14
- Magic embryology: signals that connect neurons -
David Turell,
2019-12-23, 19:08
- Magic embryology: video egg to organism in 6 minutes -
David Turell,
2019-12-23, 15:01
- Magic embryology: little understood -
David Turell,
2019-12-09, 15:38
- Magic embryology: how stem cells follow genetic instructions -
David Turell,
2019-11-08, 19:36
- Magic embryology: developing brain neuron clusters -
David Turell,
2019-10-09, 18:48
- Magic embryology: developing an immune and blood systems -
David Turell,
2019-10-09, 18:32
- Magic embryology: What guides limbs? electric patterns -
David Turell,
2019-10-08, 05:08
- Magic embryology: What guides nerve pathways to muscles? -
David Turell,
2019-03-23, 17:48
- Magic embryology: it is all in the timing -
David Turell,
2018-10-19, 20:51
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-18, 15:28
- Magic embryology: how the placenta appears -
David Turell,
2020-10-01, 21:19
- Magic embryology: how the placenta appears - David Turell, 2020-10-25, 18:13
- Magic embryology: first breath controls -
David Turell,
2020-12-06, 00:07
- Magic embryology: master gene controls in embryo forming -
David Turell,
2020-12-22, 18:54
- Magic embryology: sticky cells group together - David Turell, 2020-12-25, 18:54
- Magic embryology: placenta like no other organ -
David Turell,
2021-03-10, 18:23
- Magic embryology: DNA controls over cell migration -
David Turell,
2021-03-30, 21:48
- Magic embryology: embryo cells have specific instructions -
David Turell,
2021-04-12, 19:07
- Magic embryology: embryo cells push and pull others -
David Turell,
2021-04-12, 19:43
- Magic embryology: embryo timekeeper -
David Turell,
2021-04-28, 18:18
- Magic embryology: control of differentiation -
David Turell,
2021-06-14, 19:08
- Magic embryology: control of head to toe differentiation -
David Turell,
2021-06-17, 21:32
- Magic embryology: microglia help prune synapses -
David Turell,
2021-08-28, 14:44
- Magic embryology: multiple switches guide limb formation -
David Turell,
2021-09-29, 19:46
- Magic embryology: control of differentiation -
David Turell,
2021-11-09, 15:48
- Magic embryology: GPS for forms -
David Turell,
2021-11-11, 18:12
- Magic embryology: timing controls -
David Turell,
2022-01-25, 20:10
- Magic embryology: cells using mechanical forces -
David Turell,
2022-02-14, 18:04
- Magic embryology: independent early cells -
David Turell,
2022-02-15, 17:16
- Magic embryology: differentiation control -
David Turell,
2022-02-21, 20:38
- Magic embryology: how do stem cells reach a destination -
David Turell,
2022-03-28, 20:28
- Magic embryology: asymmetric cell division -
David Turell,
2022-03-29, 21:45
- Magic embryology: setting initial geography -
David Turell,
2022-05-14, 16:26
- Magic embryology: forming a neural tube -
David Turell,
2022-05-16, 20:20
- Magic embryology: control over placental growth -
David Turell,
2022-06-13, 19:42
- Magic embryology: -
David Turell,
2022-07-31, 23:05
- Magic embryology: controlled aging -
David Turell,
2022-11-10, 17:47
- Magic embryology: sculpting in new h[uman -
David Turell,
2022-12-21, 21:32
- Magic embryology: sculpting a new heart -
David Turell,
2023-03-30, 19:10
- Magic embryology: gene controls in insects -
David Turell,
2023-05-25, 18:16
- Magic embryology: a vital protein for fetal development -
David Turell,
2023-05-31, 19:15
- Magic embryology: all building blocks are the same -
David Turell,
2023-06-13, 18:51
- Magic embryology: tight cell junctions control events -
David Turell,
2023-07-18, 14:16
- Magic embryology: jumpstarting embryogenesis -
David Turell,
2023-07-24, 01:12
- Magic embryology: neuron movements -
David Turell,
2023-08-09, 18:02
- Magic embryology: yoke sac functions -
David Turell,
2023-08-18, 20:20
- Magic embryology: turning on a heartbeat -
David Turell,
2023-10-01, 18:08
- Magic embryology: tiny tubules connecting cells -
David Turell,
2023-11-05, 16:32
- Magic embryology: mechanical forces effect stem cells -
David Turell,
2023-11-24, 18:03
- Magic embryology: more on mechanical forces -
David Turell,
2024-01-10, 21:02
- Magic embryology: a role of microglia -
David Turell,
2024-02-03, 15:38
- Magic embryology: origin of the pituitary -
David Turell,
2024-02-03, 19:56
- Magic embryology: how to grow a limb -
David Turell,
2024-02-05, 18:31
- Magic embryology: how first cells control development -
David Turell,
2024-05-13, 17:51
- Magic embryology: from initial chaos -
David Turell,
2024-10-11, 19:38
- Magic embryology: genome and mechanical forces - David Turell, 2024-10-16, 21:53
- Magic embryology: from initial chaos -
David Turell,
2024-10-11, 19:38
- Magic embryology: how first cells control development -
David Turell,
2024-05-13, 17:51
- Magic embryology: how to grow a limb -
David Turell,
2024-02-05, 18:31
- Magic embryology: origin of the pituitary -
David Turell,
2024-02-03, 19:56
- Magic embryology: a role of microglia -
David Turell,
2024-02-03, 15:38
- Magic embryology: more on mechanical forces -
David Turell,
2024-01-10, 21:02
- Magic embryology: mechanical forces effect stem cells -
David Turell,
2023-11-24, 18:03
- Magic embryology: tiny tubules connecting cells -
David Turell,
2023-11-05, 16:32
- Magic embryology: turning on a heartbeat -
David Turell,
2023-10-01, 18:08
- Magic embryology: yoke sac functions -
David Turell,
2023-08-18, 20:20
- Magic embryology: neuron movements -
David Turell,
2023-08-09, 18:02
- Magic embryology: jumpstarting embryogenesis -
David Turell,
2023-07-24, 01:12
- Magic embryology: tight cell junctions control events -
David Turell,
2023-07-18, 14:16
- Magic embryology: all building blocks are the same -
David Turell,
2023-06-13, 18:51
- Magic embryology: a vital protein for fetal development -
David Turell,
2023-05-31, 19:15
- Magic embryology: gene controls in insects -
David Turell,
2023-05-25, 18:16
- Magic embryology: sculpting a new heart -
David Turell,
2023-03-30, 19:10
- Magic embryology: sculpting in new h[uman -
David Turell,
2022-12-21, 21:32
- Magic embryology: controlled aging -
David Turell,
2022-11-10, 17:47
- Magic embryology: -
David Turell,
2022-07-31, 23:05
- Magic embryology: control over placental growth -
David Turell,
2022-06-13, 19:42
- Magic embryology: forming a neural tube -
David Turell,
2022-05-16, 20:20
- Magic embryology: setting initial geography -
David Turell,
2022-05-14, 16:26
- Magic embryology: asymmetric cell division -
David Turell,
2022-03-29, 21:45
- Magic embryology: how do stem cells reach a destination -
David Turell,
2022-03-28, 20:28
- Magic embryology: differentiation control -
David Turell,
2022-02-21, 20:38
- Magic embryology: independent early cells -
David Turell,
2022-02-15, 17:16
- Magic embryology: cells using mechanical forces -
David Turell,
2022-02-14, 18:04
- Magic embryology: timing controls -
David Turell,
2022-01-25, 20:10
- Magic embryology: GPS for forms -
David Turell,
2021-11-11, 18:12
- Magic embryology: control of differentiation -
David Turell,
2021-11-09, 15:48
- Magic embryology: multiple switches guide limb formation -
David Turell,
2021-09-29, 19:46
- Magic embryology: microglia help prune synapses -
David Turell,
2021-08-28, 14:44
- Magic embryology: control of head to toe differentiation -
David Turell,
2021-06-17, 21:32
- Magic embryology: control of differentiation -
David Turell,
2021-06-14, 19:08
- Magic embryology: embryo timekeeper -
David Turell,
2021-04-28, 18:18
- Magic embryology: embryo cells push and pull others -
David Turell,
2021-04-12, 19:43
- Magic embryology: embryo cells have specific instructions -
David Turell,
2021-04-12, 19:07
- Magic embryology: DNA controls over cell migration -
David Turell,
2021-03-30, 21:48
- Magic embryology: master gene controls in embryo forming -
David Turell,
2020-12-22, 18:54
- Magic embryology: placenta maintains symmetry -
dhw,
2018-09-18, 13:33
- Magic embryology: placenta maintains symmetry -
Balance_Maintained,
2018-09-18, 00:42
- Magic embryology: placenta maintains symmetry -
David Turell,
2018-09-17, 21:14
- Magic embryology: physical forces form organs -
David Turell,
2018-09-12, 14:48
- Magic embryology: physical forces form organs -
dhw,
2018-09-12, 09:00
- Magic embryology: physical forces form organs -
David Turell,
2018-09-11, 14:02
- Magic embryology: physical forces form organs -
dhw,
2018-09-11, 13:15
- Magic embryology: physical forces form organs -
Balance_Maintained,
2018-09-10, 17:15
- Magic embryology: physical forces form organs -
dhw,
2018-09-10, 09:38
- Magic embryology: physical forces form organs -
David Turell,
2018-09-06, 14:00
- Magic embryology: physical forces form organs -
Balance_Maintained,
2018-09-06, 04:05
- Magic embryology: physical forces form organs -
David Turell,
2018-09-05, 21:04
- Magic embryology: egg sends protein signal to guide sperm -
David Turell,
2018-08-04, 23:07
- Magic embryology: seed to plant needs complex steps -
David Turell,
2018-08-02, 22:12
- Magic embryology: forming a blastocyst envelope: -
David Turell,
2018-08-01, 23:01
- Magic embryology: forming fetus totally unexplained -
David Turell,
2018-04-16, 00:50
- Magic embryology: forming fetus totally unexplained -
David Turell,
2018-01-27, 21:33
- Magic embryology:extensive programming on display -
David Turell,
2018-01-27, 14:55
- Magic embryology:extensive programming on display -
dhw,
2018-01-27, 13:22
- Magic embryology:extensive programming on display -
David Turell,
2018-01-27, 00:22
- Magic embryology:extensive programming on display -
dhw,
2018-01-26, 13:31
- Magic embryology:extensive programming on display -
David Turell,
2018-01-24, 15:17
- Magic embryology:extensive programming on display -
dhw,
2018-01-24, 13:57
- Magic embryology:extensive programming on display -
David Turell,
2018-01-23, 14:50
- Magic embryology:extensive programming on display -
dhw,
2018-01-23, 12:52
- Magic embryology:extensive programming on display -
David Turell,
2018-01-22, 15:00
- Magic embryology:extensive programming on display -
dhw,
2018-01-22, 14:30
- Magic embryology:extensive programming on display -
David Turell,
2018-01-21, 21:32
- Magic embryology:extensive programming on display -
David Turell,
2017-12-13, 18:28