Theoretical origin of life: Asgard archaea and viruses (Introduction)

by David Turell , Monday, June 27, 2022, 19:40 (880 days ago) @ David Turell

Makes more sense than the usual intelligent design in a lab:

https://phys.org/news/2022-06-virus-discovery-clues-complex-life.html

"There is a well-supported hypothesis that all complex life forms such as humans, starfish and trees—which feature cells with a nucleus and are called eukaryotes—originated when archaea and bacteria merged to form a hybrid organism. Recent research suggests the first eukaryotes are direct descendants of so-called Asgard archaea. The latest research, by Ian Rambo (a former doctoral student at UT Austin) and other members of Brett Baker's lab, sheds light on how viruses, too, might have played a role in this billions-year-old history.

"'This study is opening a door to better resolving the origin of eukaryotes and understanding the role of viruses in the ecology and evolution of Asgard archaea," Rambo said. "There is a hypothesis that viruses may have contributed to the emergence of complex cellular life."

"Rambo is referring to a hotly debated hypothesis called viral eukaryogenesis. It suggests that, in addition to bacteria and archaea, viruses might have contributed some genetic component to the development of eukaryotes. This latest discovery does not settle that debate, but it does offer some interesting clues.

"The newly discovered viruses that infect currently living Asgard archaea do have some features similar to viruses that infect eukaryotes, including the ability to copy their own DNA and hijack protein modification systems of their hosts. The fact that these recovered Asgard viruses display characteristics of both viruses that infect eukaryotes and prokaryotes, which have cells without a nucleus, makes them unique since they are not exactly like those that infect other archaea or complex life forms.

"'The most exciting thing is they are completely new types of viruses that are different from those that we've seen before in archaea and eukaryotes, infecting our microbial relatives," said Baker, associate professor of marine science and integrative biology and corresponding author of the study.

"The Asgard archaea, which probably evolved more than 2 billion years ago and whose descendents are still living, have been discovered in deep sea sediments and hot springs around the world, but so far only one strain has been successfully grown in the lab. To identify them, scientists collect their genetic material from the environment and then piece together their genomes. In this latest study, the researchers scanned the Asgard genomes for repeating DNA regions known as CRISPR arrays, which contain small pieces of viral DNA that can be precisely matched to viruses that previously infected these microbes. These genetic "fingerprints" allowed them to identify these stealthy viral invaders that infect organisms with key roles in the complex origin story of eukaryotes.

"'We are now starting to understand the implication and role that viruses could have had in the eukaryogenesis puzzle," said Valerie De Anda, a research associate at UT Austin and co-author of the study."

Comment: I know this does not explain origin of life but does help us see the probable role of viruses in guiding evolution.