Back to theodicy and David's theories:fixing genome mistakes (The nature of a \'Creator\')

by David Turell @, Thursday, April 01, 2021, 23:54 (504 days ago) @ David Turell

Returning vision with an RNA injection in the eye:

"A Penn Medicine patient with a genetic form of childhood blindness gained vision, which lasted more than a year, after receiving a single injection of an experimental RNA therapy into the eye.


"The treatment was designed for patients diagnosed with Leber congenital amaurosis (LCA) -- an eye disorder that primarily affects the retina -- who have a CEP290 mutation, which is one of the more commonly implicated genes in patients with the disease. Patients with this form of LCA suffer from severe visual impairment, typically beginning in infancy.

"'Our results set a new standard of what biological improvements are possible with antisense oligonucleotide therapy in LCA caused by CEP290 mutations," said co-lead author Artur V. Cideciyan, PhD, a research professor of Ophthalmology. "Importantly, we established a comparator for currently-ongoing gene editing therapies for the same disease, which will allow comparison of the relative merits of two different interventions."


"One reason why antisense oligonucleotide has proven successful in treating this rare disease, according to the researchers, is that these tiny RNA molecules are small enough to get into the cell nucleus, but are not cleared very quickly, so they remain long enough to do their work.

"'There are now, at least in the eye field, a series of clinical trials using antisense oligonucleotides for different genetic defects spawned by the success of the work in CEP290-associated LCA from Drs. Cideciyan and Jacobson," said Joan O'Brien, MD, chair of Ophthalmology in the Perelman School of Medicine and director of the Scheie Eye Institute."

Comment: Here is proof of my thought that our God-given brains can correct biochemical genomic errors beyond God's control systems. Perhaps that was His reason for The enormous ability of our brains, far beyond survival needs, an observati9n you can't answer meaningfully.

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