Brain complexity: Dopamine levels and memory (Introduction)

by David Turell , Sunday, June 05, 2016, 23:18 (3093 days ago) @ David Turell

Research has shown how different regions of the brain disengage during working memory by changing dopamine levels: - http://medicalxpress.com/news/2016-06-reveals-interaction-neural-networks-memory.html - How does the cross-talk between brain networks change when working memory - the mental assembly of information needed to carry out a particular task—is engaged? Investigators at Massachusetts General Hospital (MGH) have found that dopamine signaling within the cerebral cortex can predict changes in the extent of communication between key brain networks during working memory. - *** - Our principal finding is that dopamine signaling within the cortex predicts the extent to which the frontoparietal control network—which directly mediates working memory performance—becomes disconnected from the default network - which is active when the brain is awake but directed towards internal tasks, such as thinking about past or future events," says Joshua Roffman, MD, of the MGH Department of Psychiatry, lead and corresponding author of the paper. "The disengagement of these two networks is what allows us to shift our focus away from internal events and towards the performance of many types of cognitive tasks." - *** - After first confirming that connection between the frontoparietal control network and the default network abruptly drops when healthy volunteers begin engaging in a working memory task, the researchers then showed that the disengagement between the two networks was strongest in individuals with the lowest cortical density of D1 receptors, which reflects higher dopamine levels. D1 receptor density did not affect how accurately study participants completed the memory task. - *** - An associate professor of Psychiatry at Harvard Medical School, Roffman notes that this result is in line with previous studies in primate models showing that dopamine signaling on a cellular level is essential to a key aspect of working memory - determining which neural signals to pay attention to and which to ignore. This study is the first to examine how this cellular-level activity is expanded to a network-wide level in the brains of healthy humans. He states, "We hope that improved understanding of the role of dopamine in organizing cortical networks will lead us to better ways of improving working memory in patients with schizophrenia and other illnesses through optimized dopamine signaling." - Comment:This study clearly shows that both electrical signals and dopamine molecules work in a coordinated fashion as we shift tasks. The brain works for us.