Biochemical controls: lipoprotein levels in pregnancy (Introduction)

by David Turell , Thursday, August 22, 2024, 18:33 (91 days ago) @ David Turell

Controlled by liver-x receptor:

https://medicalxpress.com/news/2024-08-molecular-mechanism-important-dietary-fats.html

"Research in mouse models has identified a new mechanism for how long-chain polyunsaturated fatty acids (LC-PUFAs), like omega-3s, are transported from the mother to the fetus during pregnancy.

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"LC-PUFAs are a group of fatty acids that are essential to the functioning of the body. They are used in cell walls, provide an essential layer of insulation (known as myelin) around nerve cells, and are involved in a range of processes in human cells. There are two groups of LC-PUFAs—omega-3s and omega-6s.

"As humans, we can't create our own LC-PUFAs, and so we must acquire them through our diets. LC-PUFA deficiency during pregnancy can lead to a number of complications, including stillbirth, fetal growth problems and an increased chance of neurodevelopmental problems in the child.

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"Pregnant mice had much higher levels of LC-PUFAs in their blood lipoproteins. When the placenta detects these lipoproteins, it pulls out the LC-PUFAs from them to deliver the essential fatty acids to the fetus.

"The researchers also took advantage of a computational gene expression profiling technique that can identify how genes controlling this process are turned on and off. The "Liver X Receptor"—a protein that switches on the genes that control the metabolism of fats—was found to be activated during late pregnancy and linked to a significant increase in the supply of LC-PUFAs within pregnant mice. When the Liver X Receptor was deleted from the mothers' genetic code, the levels of LC-PUFAs were halved in the fetus.

"'Our study has shed light on a new mechanism for how a mother mobilizes her fuel sources to feed the baby. We know very little about the biology of women, as in the past it was assumed that female biology was the same as male biology. Historically, women weren't included in medical studies, and animal models of metabolic biology were done using only male mice.

"'By better understanding the biology of how a mother transports nutrients to the fetus, we'll be able to intervene in much cleverer ways to prevent LC-PUFA deficiency and adverse outcomes," says Charalambous."

Comment; Again, we see a specifically designed protein in control of a mechanism.