Biochemical controls: intracellular garbage removal (Introduction)

by David Turell , Wednesday, September 27, 2023, 18:28 (213 days ago) @ David Turell

Cell organelles known as 'peroxisomes' dispose toxic substances and fats:

https://www.sciencedaily.com/releases/2023/09/230927003432.htm

"'We can imagine peroxisomes being like miniature factories which specialise in different tasks," Gatsogiannis explains. "First of all, they are known for 'detoxifying' the cell. They act as cellular waste disposal units in our cells." This waste can be excess fatty acids, for example, or toxic substances from the environment: at least 50 different processes of this kind are attended to by cell organelles only 0.5 micrometres in size (1 micrometre = 1 millionth of a millimetre).

"Something that is particularly important for the system is the role played by peroxisomes in fat metabolism. This is because they not only dismantle the fats, they also convert them into usable energy which itself is indispensable for a variety of processes in the body. Without peroxisomes, dangerous quantities of certain fats can accumulate, which would give rise to serious health problems.

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"Each of these processes requires a series of specific enzymes. The peroxisomes, however, are surrounded by a biological membrane which the proteins cannot readily permeate, which means that they have to be imported. This importing mechanism needs energy and a further group of proteins -- the Pex group. "Just like a truck, which transports products from one place to another, the transportation of enzymes requires a transportation protein, energy and well-thought out logistics in order to work efficiently," is the comparison drawn by PhD student Maximilian Rüttermann, a member of the team. "And, again just like a truck, the protein is used again or recycled until ultimately it falls apart or disintegrates."

"This recycling mechanism is the only energy-intensive step in the entire importing process. The main role is played by the perixisomal AAA-ATPase complex Pex1/Pex6: this "biological nanomachine" unpacks and unfolds the spent proteins so that they can be recycled or disposed of. AAA-ATPases are basically a kind of cellular cleaning crew which keeps the inner surroundings of the cell clean, functional and ready for the demands of life.

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"The high-resolution structures show how the Pex1 and Pex6 proteins work together synchronically. They pull out of the membrane a substrate similar to the import receptors used in order to enable them to be recycled -- a unique mechanism, comparable to a row of arms which, step by step, pull a thick rope in pairs and, in the process, untie its knots. "The atomic structures and an understanding of the mechanism of this complex nanomachine now enable us to understand important steps in peroxisome physiology in health and disease," says Gatsogiannis in conclusion."

Comment: this is a vital irreducibly complex mechanism without which cells would die. From teh article: "most of the malfunctions in peroxisomal biogenesis are associated with mutations in Pex1 or Pex6, with up to 60 percent of all cases being attributable to a rare genetic disorder in which the patient's cells are not able to form peroxisomes. This is something which the general public is not aware of, as patients affected die as a rule just a few days or weeks after their birth -- and there is no known cure as yet." Only a designer could create this necessary mechanism.