Biochemical controls: controlling cell protein output (Introduction)
The body has control systems that drive production and slow production in a tight fashion:
https://phys.org/news/2022-05-decoding-protein-cells-healthy.html
"Cells produce proteins like little factories. But if they make too much at the wrong times it can lead to diseases like cancer, so they control production with a process called RNA interference (RNAi).
***
"They [a research group] recently discovered how RNAi's workhorse protein Argonaute (Ago) leverages limited resources to keep protein production on track.
"It's important to understand exactly how RNAi works because it's such a basic and heavily used process, Joshua-Tor said. It also offers a kind of safety net for therapeutics because it doesn't make permanent changes to cells and can be reversed.
***
"Ago helps cut off protein production by finding, binding, and destroying molecules called mRNA—which tell cells to make proteins. But the amount of Ago in the body pales in comparison to the amount of mRNA it must target. After destroying one MRNA molecule, the protein is still capable of finding another but it can't move on without help. Bibel discovered how cells use a process called phosphorylation to break Ago's grip on a mRNA target, allowing it to commute to the next.
"Bibel explains that their "theory is that having phosphorylation promote release is a way that you could free up Argonaute because when the target gets released, the guide's still there and it's super duper stable. So our thinking is that by phosphorylating it, you're going to free it to go repress other targets—because it's still totally capable of doing that work.'"
Comment: more evidence of purposeful design. Controlling production rates is vital, so start and stop controls must be designed together all at once.
Complete thread:
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- Biochemical controls: not in the genes!: -
David Turell,
2024-02-28, 18:57
- Biochemical controls: managing allergy -
David Turell,
2024-02-08, 20:34
- Biochemical controls: mitochondrial energy output -
David Turell,
2024-01-21, 20:02
- Biochemical controls: intercellular communication -
David Turell,
2024-01-19, 19:10
- Biochemical controls: cellular molecular decision making -
David Turell,
2024-01-18, 18:59
- Biochemical controls: mitochondrial vast activities -
David Turell,
2024-01-08, 19:04
- Biochemical controls: how age is controlled -
David Turell,
2024-01-08, 17:35
- Biochemical controls: cell adhesion controls -
David Turell,
2024-01-08, 17:17
- Biochemical controls: cellular health controls -
David Turell,
2024-01-06, 20:05
- Biochemical controls: intracellular reactions -
David Turell,
2023-12-21, 20:16
- Biochemical controls: enormous number of molecular reactions -
David Turell,
2023-12-11, 19:55
- Biochemical controls: enzymes control insulin level -
David Turell,
2023-12-06, 14:59
- Biochemical controls: reading DNA -
David Turell,
2023-11-24, 22:19
- Biochemical controls: condensate formation in cells -
David Turell,
2023-11-13, 22:00
- Biochemical controls: how T cells fight cancer -
David Turell,
2023-11-11, 16:55
- Biochemical controls: how mitochondria protect themselves -
David Turell,
2023-11-10, 19:09
- Biophysical controls: motors looping DNA -
David Turell,
2023-11-10, 15:54
- Biophysical controls -
David Turell,
2023-10-25, 21:36
- Biochemical controls: handling stress -
David Turell,
2023-10-16, 18:59
- Biochemical controls: making operational synapses -
David Turell,
2023-10-12, 21:35
- Biochemical controls: new cell division discovery -
dhw,
2023-10-08, 11:47
- Biochemical controls: new cell division discovery -
GateKeeper,
2023-10-08, 00:24
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David Turell,
2023-08-26, 20:33
- Biochemical controls: treadmilling for cell division -
David Turell,
2023-08-25, 20:54
- Biochemical controls: cell control of mRNA -
David Turell,
2023-08-25, 20:42
- Biochemical controls: molecular language -
David Turell,
2023-08-17, 17:19
- Biochemical controls: nucleolus formation -
David Turell,
2023-08-15, 17:10
- Biochemical controls: cell division atomic level -
David Turell,
2023-08-14, 17:40
- Biochemical controls: plant controls for gravity -
David Turell,
2023-08-13, 23:08
- Biochemical controls: FUBI's role -
David Turell,
2023-08-12, 00:19
- Biochemical controls: molecular movements -
David Turell,
2023-08-10, 18:52
- Biochemical controls: making insulin -
David Turell,
2023-07-25, 18:02
- Biochemical controls: parasites control hosts -
David Turell,
2023-07-20, 18:05
- Biochemical controls: expanding bacterial walls -
David Turell,
2023-07-20, 17:43
- Biochemical controls: oxygen without photosynthesis -
David Turell,
2023-07-17, 16:52
- Biochemical controls: plant root growth factors -
David Turell,
2023-07-08, 18:23
- Biochemical controls: intracellular quantum actions - David Turell, 2023-09-09, 21:25
- Biochemical controls: photosynthesis from one photon -
David Turell,
2023-07-05, 16:10
- Biochemical controls: photosynthesis from one photon -
David Turell,
2023-07-03, 22:49
- Biochemical controls: photosynthesis in phytoplankton -
David Turell,
2023-06-02, 19:13
- Biochemical controls: photosynthesis in algae -
David Turell,
2023-02-01, 16:03
- Biochemical controls: potassium regulation -
David Turell,
2023-01-30, 23:58
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David Turell,
2023-03-22, 20:26
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2023-06-19, 15:56
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2023-06-29, 17:19
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- Biochemical controls: cell conversion controls -
David Turell,
2023-06-29, 17:19
- Biochemical controls: specialized retinal synapses -
David Turell,
2023-06-19, 15:56
- Biochemical controls: intracellular electrical controls -
David Turell,
2022-09-10, 15:54
- Biochemical controls: controlling cell protein output -
David Turell,
2022-05-31, 19:20
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