Genome complexity: transposon (jumping gene) controls (Introduction)

by David Turell , Thursday, July 11, 2024, 20:54 (135 days ago) @ David Turell

Found in a plaant:

https://www.sciencedaily.com/releases/2024/07/240711111459.htm

"International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents the transcription of "jumping genes." DDM1 makes "jumping genes" more accessible for transcription-suppressing chemical marks to be deposited. Because a variant of this protein exists in humans, the discovery provides insight into genetic conditions caused by such "jumping gene" mutations.

"Disentangled DNA is often referred to as a "string." In a cell, however, it looks more like a "string ball," only the looping patterns are much more complex. The smallest unit is called a nucleosome. It consists of a section of DNA wrapped around a protein (histone) scaffolding. Transposons, genes that can "jump" to different locations in the genome, are "tucked away" in nucleosomes, which makes it difficult for the cell to deposit chemical marks that suppress transposon transcription. DDM1 is a protein known for maintaining such suppressing chemical marks, but it has not been clear how it can access transposons when they are neatly "tucked away."

"'Jumping genes are fascinating," says Osakabe, the first author of the paper, "because they can cause significant changes in the genome, both good and bad. Studying how proteins like DDM1 manage these genes helps us understand the basic mechanisms of life and can have important practical applications."

***

"The high-resolution images showed the exact positions where DDM1 bound to the DNA in the nucleosome. As a result, the specific binding site, which normally closes the nucleosome, got more "flexible" and opened up to allow suppressing chemical marks to be deposited, preventing transposons from being transcribed.

"This seemingly minor detail could be the start of major improvements.

"'The human version of DDM1, called HELLS, works similarly," says Osakabe. "In the long term, such discoveries could lead to new treatments for genetic diseases in humans caused by similar genes. This new knowledge also provides insights into how plants and other organisms control their DNA, which could improve our ability to grow better crops or develop new biotechnologies.'"

Comment: jumping genes seemed uncontrolled, appearing anywhere. Now we know they are controlled, not rogue elements. Everything in the genome is there for a reason. Purposelessness in evolution does not exist, except in Darwin's theory.