Genome Complexity; T cells alternative splicing (Introduction)

by David Turell , Tuesday, April 21, 2015, 14:34 (3505 days ago) @ David Turell

T cells fight infection. They are cells stacked in AIDS and HIV. they must make varied responses to each different infection. Alternative splicing of DNA to create different mRNA's accomplishes the feat:-"RNA is both the bridge between DNA and the production of proteins that carry out the functions of life and what guides which and how much protein gets made. As messenger RNA (mRNA) is transcribed from DNA to carry genetic information out of the nucleus, segments that don't code for actual proteins need to be removed from the RNA strand and the remaining pieces spliced together. Different pieces of the expressed gene (exons) are cut out, and these sections are joined together to form the final mRNA strand. Cells gain their ability to produce proteins with various functions by using variations of this splicing.-"The lab of Kristen Lynch, PhD, a professor of in the departments of Biochemistry & Biophysics and Genetics, at the Perelman School of Medicine at the University of Pennsylvania, studies how this splicing occurs in T cells and how it is regulated by multiple proteins. A new study published in the Proceedings of the National Academy of Sciences from her lab describes a cascade of events that may explain changes in gene expression that occur during the development of the human immune system.-"'An understanding of the patterns and mechanisms of alternative splicing is essential for a full comprehension how the genome is interpreted under different conditions to affect protein function," says Lynch.
Alternative splicing is a key mechanism for gene regulation that is regulated in response to developmental and antigen signaling in T cells. However, the extent and mechanisms of regulated splicing, particularly during T-cell development, have not been well characterized. T cells need all kinds of new proteins to go through the necessary alterations to fight infections or mature. The cells do this two ways: turn new genes on to produce new proteins or change how mRNA is spliced together to get different forms of the same proteins. These two mechanisms can work separately or together in a cell"- Read more at: http://phys.org/news/2015-04-messenger-rna-associated-protein-multiple-paths.html#jCp