Genome complexity in embryology: mitochondria (Introduction)

by David Turell , Monday, June 27, 2016, 14:30 (3072 days ago) @ David Turell

Only the mother's mitochondria end up in the offspring. The mechanism is found in C. elegans and it is assumed this may be the way it worksat all lev els of development:-http://www.the-scientist.com/?articles.view/articleNo/46414/title/Why-Paternal-Mitochondria-Aren-t-Passed-on-to-Offspring/&utm_campaign=NEWSLETTER_TS_The-Scientist-Daily_2016&utm_source=hs_email&utm_medium=email&utm_content=31024464&_hsenc=p2ANqtz--mMLVl8aHluBiiWWHuQrebGC2LoNlWNFNAAzuxS8omZG6yXxY95p9Z9XEnvP21r9dS6OSBl7Lv997QRUSOMSJx2kv8Jg&_hsmi=31024464/-"Researchers have uncovered a clue as to why a mother's mitochondria are passed on to her offspring while the father's are not. Studying sperm cells from the roundworm Caenorhabditis elegans, researchers at the University of Colorado, Boulder, and colleagues found that a gene called cps-6 encodes a mitochondrial endonuclease that degrades paternal mitochondrial DNA (mtDNA) following fertilization of an egg. Delaying this process can be fatal to the embryo, the team reported yesterday (June 23) in Science.-***-"Qinghua Zhou of the University of Colorado and colleagues examined the C. elegans cells using electron microscopy and tomography, finding that the paternal mitochondria started to self-destruct even before they were engulfed by autophagosomes. Using RNA analysis, the researchers identified cps-6 as an important part of this process. When this gene was removed, the paternal mitochondria persisted, resulting in increased embryo mortality.-“'This provides evidence that persistence of paternal mitochondria compromises animal development and may be the impetus for maternal inheritance of mitochondria,” the researchers wrote in their paper.-"It remains to be seen whether the same process occurs in humans, biologist Vincent Galy of the Pierre and Marie Curie University in Paris, who did not take part in the study, told Science News. “You could imagine there's a similar mechanism, but there's no demonstration yet,” he said."-Comment: Why are Daddy's toxic? Not known.