Genome complexity: why only 20 essential amino acids (Introduction)

by David Turell , Monday, May 02, 2016, 19:18 (3128 days ago) @ David Turell

New theoretical research into transfer RNA shows that the required shape of the tRNA limits the genome to only 20 coding amino acids:-http://phys.org/news/2016-05-discovery-fundamental-limit-evolution-genetic.html-
"A study performed at IRB Barcelona offers an explanation as to why the genetic code stopped growing 3,000 million years ago. This is attributed to the structure of transfer RNAs—the key molecules in the translation of genes into proteins. The genetic code is limited to 20 amino acids—the building blocks of proteins—the maximum number that prevents systematic mutations, which are fatal for life. The discovery could have applications in synthetic biology. -"Nature is constantly evolving—its limits determined only by variations that threaten the viability of species. Research into the origin and expansion of the genetic code are fundamental to explain the evolution of life. In Science Advances, a team of biologists specialised in this field explain a limitation that put the brakes on the further development of the genetic code, which is the universal set of rules that all organisms on Earth use to translate genetic sequences of nucleic acids (DNA and RNA) into the amino acid sequences that comprise the proteins that undertake cell functions.-***-"the genetic code evolved to include a maximum of 20 amino acids and that it was unable to grow further because of a functional limitation of transfer RNAs—the molecules that serve as interpreters between the language of genes and that of proteins. This halt in the increase in the complexity of life happened more than 3,000 million years ago, before the separate evolution of bacteria, eukaryotes and archaebacteria, as all organisms use the same code to produce proteins from genetic information.-"The authors of the study explain that the machinery that translates genes into proteins is unable to recognise more than 20 amino acids because it would confuse them, which would lead to constant mutations in proteins and thus the erroneous translation of genetic information "with catastrophic consequences", in Ribas' words. "Protein synthesis based on the genetic code is the decisive feature of biological systems and it is crucial to ensure faithful translation of information," says the researcher."
 
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 -"Saturation of the genetic code has its origin in transfer RNAs (tRNAs), the molecules responsible for recognising genetic information and carrying the corresponding amino acid to the ribosome, the place where chain of amino acids are made into proteins following the information encoded in a given gene. However, the cavity of the ribosome into which the tRNAs have to fit means that these molecules have to adopt an L-shape, and there is very little possibility of variation between them. "It would have been to the system's benefit to have made new amino acids because, in fact, we use more than the 20 amino acids we have, but the additional ones are incorporated through very complicated pathways that are not connected to the genetic code. And there came a point when Nature was unable to create new tRNAs that differed sufficiently from those already available without causing a problem with the identification of the correct amino acid. And this happened when 20 amino acids were reached," explains Ribas."-Comment: If God is the designer, the chemistry limits Him!