Genome complexity in embryology: egg starting (Introduction)

by David Turell , Tuesday, July 11, 2017, 23:41 (2692 days ago) @ David Turell

mRNA's from the mother helps get the fertilized egg started:

https://phys.org/news/2017-06-elegant-transition-egg-embryo.html

"The transition from an egg to a developing embryo is one of life's most remarkable transformations. Yet little is known about it. Now Whitehead Institute researchers have deciphered how one aspect—control of the all-important translation of messenger RNAs (mRNAs) into proteins—switches as the egg becomes an embryo. That shift is controlled by a beautiful mechanism, which is triggered at a precise moment in development and automatically shuts itself off after a narrow window of 20 to 90 minutes.

"As an egg develops, it stockpiles mRNAs from the mother because it will not have time to create new mRNAs during the rapid development of a very early embryo. When fertilized the egg becomes an embryo, the stashed maternal mRNAs are pressed into service for a brief window before the embryo starts transcribing its own mRNAs. This change occurs very early; in humans, only two to four cell divisions occur before this transition is executed.

" In the current research, Orr-Weaver and her lab determined that key to the transition are the three molecules that form the enzyme PNG kinase: PNG, PLU, and GNU. Orr-Weaver describes PNG and PLU as "tight buddies" that are always locked together, including in the mature egg. At that point in development, GNU has phosphate molecules tacked to it, which impede its binding to PNG-PLU.

"When an egg is activated, levels of another enzyme that adds phosphates to GNU in the egg precipitously drop, allowing GNU to lose its phosphates and bind to PNG-PLU. Once together, the trio comprises the PNG kinase that triggers the translational control of the maternal mRNAs. Because PNG kinase also triggers the break down of GNU, the kinase self-destructs, which quickly and irreversibly squelches the translation of maternal mRNAs. This elegant feedback loop and the switch it controls are described in an article in eLife. (my bold)

***

"Although she now has as greater understanding of how translation is turned on and off during very early embryonic development, Orr-Weaver is intrigued by how the switch is linked to the translation machinery.

"'PNG is a kinase, which means it controls things by what it phosphorylates," says Orr-Weaver, who is also an American Cancer Society Research Professor of biology at MIT. "So the big question is what proteins does it phosphorylate? Finding that out is the next big phase of this project.'"

Comment: Note my bold. A feedback loop must develop all at once with all of it. The enzyme is a giant molecule. Evolution did not hunt and peck for it. It has a specific purpose fro which it is designed. That is the key point. A system like this requires a designer!