Junk DNA goodbye: fear controls found (Introduction)

by David Turell , Sunday, March 27, 2022, 04:51 (973 days ago) @ David Turell

As usual in non-coding DNA (junk):

https://qbi.uq.edu.au/article/2022/03/junk-dna-key-controlling-fear

"A piece of “junk DNA” could be the key to extinguishing fear-related memories for people struggling with post-traumatic stress disorder (PTSD) and phobia, according to a study from The University of Queensland.

"An international research project, led by the Queensland Brain Institute’s Associate Professor Timothy Bredy, discovered the new gene while investigating how the genome responds to traumatic experiences.

“'Until recently, scientists thought the majority of our genes were made up of junk DNA, which essentially didn’t do anything.” Dr Bredy said.

“'But when researchers began to explore these regions, they realised that most of the genome is active and transcribed.”

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"A new gene, labelled ADRAM by the researchers, was found to not only act as a scaffold for molecules inside the cell, but also helped coordinate the formation of fear-extinction memory.

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"Until now, there have been no studies devoted to understanding these genes, let alone how they might influence brain function in the context of learning and memory.

“Our findings suggest that long non-coding RNAs provide a bridge, linking dynamic environmental signals with the mechanisms that control the way our brains respond to fear,” Dr Bredy said.

“'With this new understanding of gene activity, we can now work towards developing tools to selectively target long non-coding RNAs in the brain that directly modify memory, and hopefully, develop a new therapy for PTSD and phobia.”

"This study was published in Cell Reports (doi.org/10.1016/j.celrep.2022.110546)"

Comment: it may be boring to have me produce more findings on what seemed to be 'junk' in DNA. However Larry Moran is publishing a book still claiming most of it is junk. He won't give up despite his lonely position. I think Dan Graur is still with him. What they realize is teh old Darwin theory is dead unless junk exists showing chance appearing useless mutations in the genome.