Junk DNA goodbye!: retrotransposons (Introduction)

by David Turell , Monday, November 19, 2018, 22:35 (1981 days ago) @ David Turell

This study says retrotransposons use junk DNA to advance evolution within DNA:

https://phys.org/news/2018-11-genes-advanced-life-emerged.html

"A previously unappreciated interaction in the genome turns out to have possibly been one of the driving forces in the emergence of advanced life, billions of years ago.

"This discovery began with a curiosity for retrotransposons, known as "jumping genes," which are DNA sequences that copy and paste themselves within the genome, multiplying rapidly. Nearly half of the human genome is made up of retrotransposons, but bacteria hardly have them at all.

"When retrotransposons copy themselves within the genome, they first find a spot in the DNA and cut it open. To survive, the organism then has to repair this cut. Some bacteria, like E. coli, only have one way to perform this repair, which usually ends up removing the new retrotransposon. But advanced organisms (eukaryotes) have an additional "trick" called nonhomologous end-joining, or NHEJ, that gives them another way to repair cuts in their DNA.

"Goldenfeld and Kuhlman decided to see what would happen if they gave bacteria the ability to do NHEJ, thinking that it would help them tolerate the damage to their DNA. But it just made the retrotransposons better at multiplying, causing even more damage than before.

"It just completely killed everything," Kuhlman said. "At the time, I thought I was just doing something wrong."
They realized that the interaction between NHEJ and retrotransposons may be more important than they previously thought.

***

"Eukaryotes typically have many retrotransposons in their genome, along with a lot of other "junk" DNA, which doesn't have a well-understood function. Within the genome, there must be a constant interplay between NHEJ and retrotransposons, as NHEJ tries to control how rapidly the retrotransposons multiply. This gives the organism more power over their genome, and the presence of "junk" DNA is important.

"'As you get more and more junk in your DNA, you can start taking these pieces and combining them together in different ways, more ways than you could without all the junk in there," Kuhlman said.

"These conditions—the accumulation of "junk" DNA, the presence of retrotransposons and their interactions with NHEJ—make the genome more complex. This is one feature that may distinguish advanced organisms, like humans, from simpler ones, like bacteria.
"Advanced organisms can also manage their genome by using their spliceosome, a molecular machine that sorts through the "junk" DNA and reconstructs the genes back to normal.

"Some parts of the spliceosome are similar to group II introns, bacteria's primitive version of retrotransposons. Introns are also found in eukaryotes, and along with the spliceosome are evolutionarily derived from group II introns. Goldenfeld said this poses an evolutionary question.

"'What came first, the spliceosome or the group II introns? Clearly the group II introns," he said. "So then you can ask: where did the eukaryotic cell first get those group II introns in order to build up the spliceosome early on?"

"This study suggests that group II introns, the ancestors of introns in the spliceosome and retrotransposons in eukaryotes, somehow invaded early eukaryotic cells. Then, their interactions with NHEJ created a "selection pressure" that helped lead to the emergence of the spliceosome, which helped life become advanced billions of years ago.

"The spliceosome helped life become advanced by enabling eukaryotes to do more with their DNA. For example, even though humans have roughly the same number of genes as C. elegans, a worm, humans can do more with those genes. (my bold)

"'There's not much difference between this very simple worm and humans, which is obviously insane," Goldenfeld said. "What's happening is that humans are able to take these genes and mix and match them in many combinations to do much more complicated functions than C. elegans does."

"Not only did NHEJ and retrotransposons help with the creation of the spliceosome; this study suggests that they may also have assisted in making chromosomes—DNA molecules that contain genetic material—more advanced. Interactions between NHEJ and retrotransposons may have aided in the transition from circular chromosomes (which bacteria generally have) to linear ones (which more advanced organisms have), another indicator of advanced life.

"Goldenfeld said that before this research, many researchers studied the role of retrotransposons, but the importance of NHEJ was not fully appreciated. This research proves that it played a part, billions of years ago, in eukaryotes becoming the advanced organisms we know today.

"'This certainly was not the only thing that was going on," Goldenfeld said. "But if it hadn't happened, it's hard to see how you could have complex life.'"

Comment: Once again junk DNA is necessary. This could well explain how advances in evolution were coded into DNA, by simply rearranging DNA, with no need for enlargement. Perhaps this is what ID scientists view as devolution. The authors assume chance evolution. I think God used this method .