Junk DNA goodbye!: circular RNA helps heart attacks (Introduction)

by David Turell , Monday, September 23, 2019, 01:53 (1678 days ago) @ David Turell

Circular RNA's have a disposal function in cell damage:

https://www.sciencedaily.com/releases/2019/09/190920081901.htm

"The human genetic blueprint is like a string of code. To follow it, the code, or DNA, is transcribed into shorter strings of RNA. While some of these shorter strings carry instructions for making proteins -- the functional units of cells -- most RNA is not involved in protein production. Among these noncoding RNAs are the recently discovered circular RNAs, so-named because of their unusual ring shape (most other RNAs are linear).

"Circular RNAs, like other noncoding RNAs, were thought to be nonfunctional, but recent evidence suggests otherwise. Circular RNAs may in fact act like sponges to "soak up," or bind, other molecules, including microRNAs and proteins, and now, new work by researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) and colleagues supports this idea. They describe, for the first time, a circular RNA that fills a critical role in tissue repair after heart attack, thanks to its ability to soak up harmful molecules.

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"Dr. Kishore and colleagues focused their investigation on circFndc3b after finding that this particular circular RNA was significantly decreased in the heart in mice that had experienced a heart attack. "This observation led us to wonder whether the change in circFndc3b expression meant that it was important functionally in the heart," Dr. Kishore said.

"To investigate this possibility, a gene product to induce circFndc3b overexpression was injected into the heart in mice after heart attack. Subsequent examination showed that within eight weeks of injection, treated mice experienced gains in heart function and in survival compared to their untreated counterparts. There was also evidence within heart tissue that new blood vessels had started to form, greatly aiding the tissue repair process.

"The findings offer exciting insight into circular RNAs and the significance of their potential role as molecular sponges that limit the activity of damaging molecules. "CircFndc3b specifically soaked up an RNA binding protein that suppresses blood vessel formation," Dr. Kishore explained. "In doing so, it made way for new vessels to grow.'"

Comment: As before, the point Darwinists made for years is that junk DNA (non-coding DNA) proved chance evolution with much DNA useless. Obviously not true. All studies show most DNA cannot be from chance mechanisms, such as accidental mutations.