Genome complexity: How Archaea handle DNA (Introduction)

by David Turell , Thursday, March 11, 2021, 18:18 (1354 days ago) @ David Turell

They coil it like a slinky:

https://www.sciencenews.org/article/archaea-microbes-fold-twist-contort-dna-extreme-ways

"Single-celled archaea microbes pack their DNA into flexible coils that expand and stretch much like a Slinky does. This kind of molecular gymnastics had never been seen before in other organisms and may represent a way for archaea to get easy access to their genetic material, researchers report March 2 in eLife.

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“'You would think that this would really contort the DNA in an awful shape, but it actually flows very naturally.”

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"In 2017, Luger and her colleagues discovered that archaea — microbes that resemble bacteria under the microscope but are quite distinct — can spool their DNA around small proteins called histones (SN: 8/10/17). This process is strikingly similar to how plants, animals and fungi bend and fold their own genomes into compact, disk-shaped units known as nucleosomes.

"But nobody knew what these structures looked like in archaea, or how the microbes gained access to their spooled DNA. Using computer simulations and electron microscopy experiments on the genetic material of Methanothermus fervidus, a heat-loving archaeal species, the researchers found the Slinky-like shapes opened and closed in a clamshell motion.

“'My gut reaction was: ‘Wow! So pretty!’” says Luger. “My second reaction was: ‘Of course! This makes so much sense!’”

"Complex organisms such as humans, palm trees or mushrooms depend on a sophisticated machinery to loosen their highly compacted nucleosomes and gain access to specific genes. Archaea microbes might instead simply be contorting their DNA to turn genes on and off –– allowing proteins to “read” the genes when the Slinkies open, and cutting off access when they close."

Comment: Archaea are our oldest ancestors. This means complex DNA code reading came with or shortly after the appearance of life.