Genome complexity: chromatin makes DNA 3-D setup (Introduction)

by David Turell , Friday, January 10, 2020, 21:37 (1567 days ago) @ David Turell

The relationships that are arranged allows for many interpretations:

https://phys.org/news/2020-01-chromatin-d-forests-cells.html

"A single cell contains the genetic instructions for an entire organism. This genomic information is managed and processed by the complex machinery of chromatin—a mix of DNA and protein within chromosomes whose function and role in disease are of increasing interest to scientists.

"A Northwestern University research team—using mathematical modeling and optical imaging they developed themselves—has discovered how chromatin folds at the single-cell level. The researchers found chromatin is folded into a variety of tree-like domains spaced along a chromatin backbone. These small and large areas are like a mixed forest of trees growing from the forest floor. The overall structure is a 3-D forest at microscale.

"Chromatin is responsible for packing DNA into the cell nucleus. In humans, that's about six feet of DNA in each cell. The new work suggests that chromatin is more structured and hierarchical in single cells than previously thought. Learning how chromatin correctly operates will help scientists understand what goes wrong with it in cancer and other diseases.

"'By integrating theoretical and experimental work, we have produced a new chromatin folding picture that helps us see how the 3-D genome is organized at the single-cell level," said Igal Szleifer, the Christina Enroth-Cugell Professor of Biomedical Engineering at Northwestern's McCormick School of Engineering.

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"'If genes are the hardware, chromatin is the software," said Backman, the Walter Dill Scott Professor of Biomedical Engineering and director of the Center for Physical Genomics and Engineering. "If the structure of chromatin changes, it can alter the processing of the information stored in the genome, but it does not alter the genes themselves. Understanding chromatin folding holds the key to understanding how cells differentiate and how cancer happens.'"

Comment: The 3-D relationships determines how the genes are fully interpreted. It is one of the various layers of complex information and instructions that makes each type of cell unique..