Genome complexity; another layer (Introduction)

by David Turell @, Tuesday, December 11, 2012, 16:11 (2292 days ago) @ David Turell

A new study on the ciradian cycles shows the epigenetic controls of the mouse liver:

"In the case of humans and other vertebrates, a brain structure called the suprachiasmatic nucleus controls circadian responses. But there are also clocks throughout the body, including our visceral organs, that tell specific genes when to make the workhorse proteins that enable basic functions in our bodies, such as producing glucose for energy. In the liver, genes that control the metabolism of fat and cholesterol turn on and off in sync with these clocks. But genes do not switch on and off by themselves. Their activity is regulated by the "epigenome," a set of molecules that signal to the genes how many proteins they should make, and, most importantly from the circadian point of view, when they should be made."

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