Chimps \'r\' not us: 3-D DNA shows vast differences (Introduction)

by David Turell , Tuesday, February 16, 2021, 19:35 (1377 days ago) @ David Turell

About 30% different:

https://www.icr.org/article/human-genome-radically-different-from-chimp

"...a new study published in Trends in Genetics evaluates research in this emerging field that shows the human 3-D genome is distinctly unique to humans, confirming previous research that showed it is as different compared to chimp as it is to mouse.

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"One of the best ways to empirically understand the 3-D configuration of chromosomes in the nucleus of the cell is to define topologically associating domains (TADs) in the DNA sequence. TADs are characterized as regions whose DNA sequences preferentially contact and interact with each other in association with specific cell types and biological functions.

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"One important aspect of 3-D genome structure has to do with the epigenetic modification of proteins called histones that the DNA is wrapped around. A 2011 study showed that a specific type of histone modification had only about a 70% overlap or similarity between humans and chimps.4 Remarkably, another study in 2012 showed that humans had about a 70% similarity for the same feature with mice.5 In other words, humans were as different to mice as they were to chimps for this particular genome conformation metric.

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"They found that in comparing humans and chimps, “only ~43% of TADs conserved [similar] between these species, but across many different parameters (e.g., resolution, window size, genome assembly) and different downstream analysis decisions, no more than 78% of domains and 83% of TAD boundaries were found to be shared between humans and chimpanzees.”

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"This new study, along with many others, is continuing to debunk evolution and confirm the uniqueness of the human genome. For example, previous research by this author has shown that the human and chimp genomes are no more than 85% similar, and it’s likely the final findings will be far less than that."

Comment: We may have 98% similar bases with chimps but the 3-D DNA's are at least 78% different as discussed in our past entries.