cellular intelligence; pupillary eye controls (Evolution)

by David Turell , Thursday, April 30, 2020, 21:17 (1457 days ago) @ David Turell

There is a newly found network from the retina which controls pupillary size:

https://medicalxpress.com/news/2020-04-eyes-unexpected-brain.html

"New research, led by Northwestern University, has found that a subset of retinal neurons sends inhibitory signals to the brain. Before, researchers believed the eye only sends excitatory signals.

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"The Northwestern researchers also found that this subset of retinal neurons is involved in subconscious behaviors, such as synchronization of circadian rhythms to light/dark cycles and pupil constriction to intense bright lights. By better understanding how these neurons function, researchers can explore new pathways by which light influences our behavior.

"'These inhibitory signals prevent our circadian clock from resetting to dim light and prevent pupil constriction in low light, both of which are adaptive for proper vision and daily function," said Northwestern's Tiffany Schmidt, who led the research. "We think that our results provide a mechanism for understanding why our eye is so exquisitely sensitive to light, but our subconscious behaviors are comparatively insensitive to light."

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"To conduct the study, Schmidt and her team blocked the retinal neurons responsible for inhibitory signaling in a mouse model. When this signal was blocked, dim light was more effective at shifting the mice's circadian rhythms.

"'This suggests that there is a signal from the eye that actively inhibits circadian rhythms realignment when environmental light changes, which was unexpected," Schmidt said. "This makes some sense, however, because you do not want to adjust your body's entire clock for minor perturbations in the environmental light/dark cycle, you only want this massive adjustment to take place if the change in lighting is robust."

"Schmidt's team also found that, when the inhibitory signals from the eye were blocked, mice's pupils were much more sensitive to light.

"'Our working hypothesis is that this mechanism keeps pupils from constricting in very low light," Sonoda said. "This increases the amount of light hitting your retina, and makes it easier to see in low light conditions. This mechanism explains, in least part, why your pupils avoid constricting until bright light intensifies.'"

Comment: our eyes are exquisitely sensitive, and our night vision is a very real asset. This has to be a designed system.