cellular controls of protein paths (Evolution)

by David Turell , Thursday, March 05, 2020, 01:16 (1506 days ago) @ David Turell

The proteins are Shepherded exactly as required:

https://phys.org/news/2020-03-mechanism-cell-protein-traffic.html

"New research, published Feb. 26 in Nature Communications, identifies an enzyme—N-terminal glycine myristoyltransferases (NMT) 1 and 2—which adds lysine myristoylation to a key protein.

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"Just like a set of flight instructions directs a pilot to fly a correct route, biochemical mechanisms ordered by these enzymes give proteins directions for moving through different subcellular locations in the most efficient way, Lin said. Without the proper chemical code, a protein might travel through the cell inefficiently or incorrectly.

"'In our cells, there are certain proteins, such as ARF6, which need to go from A to B to C, then back to A, because that's what's required for transporting other proteins in a cycle," Lin said. "That's what we found—the mechanism that makes sure the protein ARF6 follows that path."

"The researchers found that this mechanism takes place in human cells of many kinds. They believe that all mammalian cells operate in a similar way.

"In addition to telling ARF6 where to go, NMT1 and NMT2 also help to activate the protein."

Comment: These molecular processes follow exact information and deliver the proteins automatically exactly where they are required to go. Of course the cells look intelligent to older researcher s from past time, until the automaticity is demonstrated now.