biomimetics great designs: designing DNA to store data (Introduction)

by David Turell , Thursday, March 03, 2022, 22:33 (996 days ago) @ David Turell

A new way copying the natural design of the genome:

https://phys.org/news/2022-03-future-storage-double-helical.html

"DNA is nature's original data storage system. We can use it to store any kind of data: images, video, music—anything," said Kasra Tabatabaei, a researcher at the Beckman Institute for Advanced Science and Technology and a co-author on this study.

"Expanding DNA's molecular makeup and developing a precise new sequencing method enabled a multi-institutional team to transform the double helix into a robust, sustainable data storage platform.

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"From scientists to social media influencers, anyone with information to store stands to benefit from a secure, sustainable data lock box—and the double helix fits the bill.

"'DNA is one of the best options, if not the best option, to store archival data especially," said Chao Pan, a graduate student at the University of Illinois Urbana-Champaign and a co-author on this study.

"Its longevity rivaled only by durability, DNA is designed to weather Earth's harshest conditions—sometimes for tens of thousands of years—and remain a viable data source. Scientists can sequence fossilized strands to uncover genetic histories and breathe life into long-lost landscapes.

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"'Every day, several petabytes of data are generated on the internet. Only one gram of DNA would be sufficient to store that data. That's how dense DNA is as a storage medium," said Tabatabaei, who is also a fifth-year Ph.D. student.

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"In nature, every strand of DNA contains four chemicals—adenine, guanine, cytosine, and thymine—often referred to by the initials A, G, C, and T. They arrange and rearrange themselves along the double helix into combinations that scientists can decode, or sequence, to make meaning.

"The researchers expanded DNA's already broad capacity for information storage by adding seven synthetic nucleobases to the existing four-letter lineup.

"'Imagine the English alphabet. If you only had four letters to use, you could only create so many words. If you had the full alphabet, you could produce limitless word combinations. That's the same with DNA. Instead of converting zeroes and ones to A, G, C, and T, we can convert zeroes and ones to A, G, C, T, and the seven new letters in the storage alphabet," Tabatabaei said.

"Because this team is the first to use chemically modified nucleotides for information storage in DNA, members innovated around a unique challenge: Not all current technology is capable of interpreting chemically modified DNA strands. To solve this problem, they combined machine learning and artificial intelligence to develop a first-of-its-kind DNA sequence readout processing method.

"Their solution can discern modified chemicals from natural ones, and differentiate each of the seven new molecules from one another.

"We tried 77 different combinations of the 11 nucleotides, and our method was able to differentiate each of them perfectly," Pan said. "The deep learning framework as part of our method to identify different nucleotides is universal, which enables the generalizability of our approach to many other applications."

"This letter-perfect translation comes courtesy of nanopores: proteins with an opening in the middle through which a DNA strand can easily pass. Remarkably, the team found that nanopores can detect and distinguish each individual monomer unit along the DNA strand—whether the units have natural or chemical origins.

"'This work provides an exciting proof-of-principle demonstration of extending macromolecular data storage to non-natural chemistries, which hold the potential to drastically increase storage density in non-traditional storage media," said Charles Schroeder, the James Economy Professor of Materials Science and Engineering and a co-PI on this study."

Comment: DNA is a fabulous coding design. It did not pop up by chance. As usual we can turn to nature to find useful solutions, and here to improve upon them. Our God-given brains are no match for His, but ours let us improve upon what He has provided.